Diffuse large B-cell lymphoma developed newly after 9-year remission of a follicular lymphoma

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  • 濾胞性リンパ腫の寛解9年後に新たに発症したびまん性大細胞型B細胞リンパ腫
  • 症例報告 濾胞性リンパ腫の寛解9年後に新たに発症したびまん性大細胞型B細胞リンパ腫
  • ショウレイ ホウコク ロホウセイ リンパシュ ノ カンカイ9ネンゴ ニ アラタ ニ ハッショウ シタ ビマンセイ ダイ サイボウガタ B サイボウ リンパシュ

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Abstract

Follicular lymphoma (FL) occasionally transforms into diffuse large B-cell lymphoma (DLBCL). This is generally associated with a poor prognosis, necessitating more potent chemotherapy as salvage treatment. However, de novo DLBCL, but not DLBCL transformed from FL, can be treated as primary DLBCL. We encountered a 63-year-old woman who developed DLBCL after a 9-year remission following treatment of FL. To differentiate DLBCL transformed from FL and de novo DLBCL, VDJ gene rearrangements in IgH were examined by PCR using biopsy specimens from both lymphomas. The results revealed the two lymphomas to be different clones. Thus, she was diagnosed with primary DLBCL. Therefore, routine chemotherapy and radiation therapy were conducted for the primary DLBCL with a limited stage, achieving complete remission. Treatment based on the clonality assessment of VDJ gene rearrangements is potentially useful for treating late relapse of B-cell lymphoma according to the pathological conditions of patients.

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  • Rinsho Ketsueki

    Rinsho Ketsueki 57 (2), 171-174, 2016

    The Japanese Society of Hematology

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