Efficacy of Intrathecal MTX/Ara-C Combined with Systemic Chemotherapy in a Gastric Cancer Patient with Meningeal Carcinomatosis
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- Yamasaki Takahisa
- Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Japan
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- Fukui Hirokazu
- Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Japan
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- Sei Hiroo
- Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Japan
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- Hara Ken
- Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Japan
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- Eda Hirotsugu
- Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Japan
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- Kondo Takashi
- Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Japan
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- Toyoshima Fumihiko
- Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Japan
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- Kono Tomoaki
- Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Japan
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- Tozawa Katsuyuki
- Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Japan
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- Ikehara Hisatomo
- Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Japan
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- Tomita Toshihiko
- Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Japan
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- Oshima Tadayuki
- Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Japan
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- Watari Jiro
- Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Japan
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- Miwa Hiroto
- Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Japan
この論文をさがす
抄録
A 35-year-old man was diagnosed to have gastric cancer by endoscopic and histological examinations. Staging laparoscopy detected peritoneal metastasis. Systemic chemotherapy was started, but the patient complained of severe headache. Subsequently, a lumbar puncture demonstrated adenocarcinoma cells in the spinal fluid, suggesting the occurrence of meningeal carcinomatosis (MC) from gastric cancer. MC occurs only rarely in patients with gastric cancer, but the prognosis is invariably poor. However, this patient nevertheless survived for 12 months after receiving intrathecal MTX/Ara-C together with systemic chemotherapy. Therefore, the early detection of meningeal irritation sign and intrathecal chemotherapy might greatly improve the prognosis of gastric cancer patients with MC.<br>
収録刊行物
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- Internal Medicine
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Internal Medicine 55 (6), 609-611, 2016
一般社団法人 日本内科学会
