Thrombocytopenia and Anemia with Anti-c-Mpl antibodies Effectively Treated with Cyclosporine in a Patient with Rheumatoid Arthritis and Chronic Renal Failure
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- Hashimoto Akari
- Department of Hematology and Oncology, Oji General Hospital, Japan
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- Kanisawa Yuji
- Department of Hematology and Oncology, Oji General Hospital, Japan
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- Fujimi Akihito
- Department of Hematology and Oncology, Oji General Hospital, Japan
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- Nakajima Chisa
- Department of Gastroenterology, Oji General Hospital, Japan
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- Hayasaka Naotaka
- Department of Gastroenterology, Oji General Hospital, Japan
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- Yamada Shota
- Department of Gastroenterology, Oji General Hospital, Japan
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- Okuda Toshinori
- Department of Gastroenterology, Oji General Hospital, Japan
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- Minami Shinya
- Department of Gastroenterology, Oji General Hospital, Japan
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- Yamauchi Natsumi
- Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine, Japan
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- Iwasaki Sari
- Department of Pathology, Hokkaido University Graduate School of Medicine, Japan
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- Suzuki Akira
- Department of Pathology, Hokkaido University Graduate School of Medicine, Japan
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- Kato Junji
- Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine, Japan
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抄録
A 61-year-old woman with rheumatoid arthritis who was undergoing hemodialysis for end-stage renal failure was transferred to our hospital due to severe thrombocytopenia and anemia. A bone marrow biopsy showed the complete absence of megakaryocytes and erythroblasts. Cyclosporine treatment resulted in the improvement of her megakaryocyte and erythroblast levels, and a decrease in her serum level of anti-c-Mpl (thrombopoietin receptor) antibodies. After this initial improvement, her anemia progressively worsened, despite the continuous administration of immunosuppressive therapy with cyclosporine. Her platelet and leukocyte counts remained stable. This is the first report of a probable case of anti-c-Mpl antibody-associated pure red cell aplasia and acquired amegakaryocytic thrombocytopenic purpura.<br>
収録刊行物
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- Internal Medicine
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Internal Medicine 55 (6), 683-687, 2016
一般社団法人 日本内科学会