Determination of Detection Limits and Quantitation Limits for Compounds in a Database of GC/MS by FUMI Theory

• Nakashima Shinya

  Department of Business Development, Science Software Co., Ltd.

• Hayashi Yuzuru

  Faculty of Pharmaceutical Sciences, Teikyo Heisei University

抄録

The aim of this paper is to propose a stochastic method for estimating the detection limits (DLs) and quantitation limits (QLs) of compounds registered in a database of a GC/MS system and prove its validity with experiments. The approach described in ISO 11843 Part 7 is adopted here as an estimation means of DL and QL, and the decafluorotriphenylphosphine (DFTPP) tuning and retention time locking are carried out for adjusting the system. Coupled with the data obtained from the system adjustment experiments, the information (noise and signal of chromatograms and calibration curves) stored in the database is used for the stochastic estimation, dispensing with the repetition measurements. Of sixty-six pesticides, the DL values obtained by the ISO method were compared with those from the statistical approach and the correlation between them was observed to be excellent with the correlation coefficient of 0.865. The accuracy of the method proposed was also examined and concluded to be satisfactory as well. The samples used are commercial products of pesticides mixtures and the uncertainty from sample preparation processes is not taken into account.

収録刊行物

• Mass Spectrometry

  Mass Spectrometry 5 (1), A0043-A0043, 2016

  一般社団法人　日本質量分析学会

キーワード

• GC/MS
• detection limit
• ISO 11843-7
• FUMI theory
• database

詳細情報

• CRID: 1390001205415352320
• NII論文ID: 130005138384
• DOI: 10.5702/massspectrometry.a0043
• ISSN: 21865116
• ISSN: 2187137X
• Web Site: https://www.jstage.jst.go.jp/article/massspectrometry/5/1/5_A0043/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可