The Role of the Adipocyte Hormone Leptin in Alzheimer’s Disease

• Ishii Makoto

  Feil Family Brain and Mind Research Institute, Department of Neurology, Weill Medical College of Cornell University, New York, USA

抄録

Cognitive deficits are the major manifestation of Alzheimer’s disease (AD); however, weight loss can precede the mental decline and correlates with disease severity. Thus, brain circuits controlling body weight may be altered early in AD and could be intrinsic to AD pathobiology. In mouse models, we found that amyloid-beta, a major pathogenic factor in AD, could inhibit hypothalamic neurons in the leptin pathway, which was associated with early body weight/metabolic deficits. Ongoing research seeks to elucidate the mechanisms underlying the body weight/metabolic deficits and hypothalamic dysfunction in AD using both mouse models and clinically relevant human studies.(Presented at the 1919th Meeting, March 2, 2016)

収録刊行物

• Ｔｈｅ　Ｋｅｉｏ　Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎｅ

  Ｔｈｅ　Ｋｅｉｏ　Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎｅ 65 (1), 21-21, 2016

  The Keio Journal of Medicine

キーワード

• General Medicine

詳細情報

• CRID: 1390001206337970304
• NII論文ID: 130005138576
• DOI: 10.2302/kjm.65-002-abst
• ISSN: 18801293
• ISSN: 00229717
• PubMed: 27040887
• Web Site: https://www.jstage.jst.go.jp/article/kjm/65/1/65_65-002-ABST/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2017035351
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可