Fatal Severe Fever with Thrombocytopenia Syndrome: An Autopsy Case Report
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- Uehara Natsumi
- Department of Internal Medicine, Miyazaki Prefectural Nobeoka Hospital, Japan
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- Yano Takao
- Department of Critical Care Medicine, Miyazaki Prefectural Nobeoka Hospital, Japan
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- Ishihara Akira
- Department of Pathology, Miyazaki Prefectural Nobeoka Hospital, Japan
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- Saijou Masayuki
- Department of Virology I, National Institute of Infectious Disease, Japan
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- Suzuki Tadaki
- Department of Pathology, National Institute of Infectious Disease, Japan
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抄録
As of June 2014, among six patients who had severe fever with thrombocytopenia syndrome (SFTS) at our hospital, an 83-year-old man died despite receiving appropriate critical care. An autopsy revealed extensive ischemic damage of the intra-abdominal organs, including the liver, spleen, stomach and gut, due to severe celiac atherosclerotic stenosis and superior mesenteric arterial thrombosis. Many SFTS virus nucleoprotein antigen-immunoreactive cells were detected in a paraaortic node, where necrotizing lymphadenitis was seen, and in the spleen. Fewer such cells were seen in the liver, bone marrow and adrenals. Conclusion: Atherosclerosis, in addition to hemophagocytic lymphohistiocytosis syndrome, can be lethal in elderly SFTS patients.<br>
収録刊行物
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- Internal Medicine
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Internal Medicine 55 (7), 831-838, 2016
一般社団法人 日本内科学会