Exposure to Mild Hypoxia Associated with Oral Breathing Affects The NK Cell Ratio in The Spleen

DOI Web Site 参考文献27件
  • Murakami Yoshiki
    Nihon University Graduate School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan
  • Yamaguchi Masaru
    Departments of Orthodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 27-8587, Japan
  • Sato Tomonori
    Departments of Orthodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 27-8587, Japan
  • Kobayashi Ryoki
    Departments of Microbiology and immunology, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan
  • Negishi Shinichi
    Departments of Orthodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 27-8587, Japan
  • Kasai Kazutaka
    Departments of Orthodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 27-8587, Japan

この論文をさがす

抄録

An upper respiratory tract obstruction due to nasopharyngeal diseases such as allergic rhinitis and tonsillar hypertrophy/sinusitis in growing children inhibits normal nasal breathing and leads to oral breathing. One symptom of this phenomenon appearing in the living body is hypoxia. Typically, it is rare for hypoxia associated with an upper respiratory obstruction to become severe and cause dyspnea, and it generally causes mild hypoxia. However, there are no previous reports regarding the effect of mild hypoxia on the living body. Thus, in this study, in order to examine the effect of mild hypoxia on the entire body, alterations in the immune system of growing rats using a mild hypoxia exposed model were evaluated.<br>　Six-week-old Wistar male rats were used(n=60)and assigned to either the mild hypoxia group(18% FIO2)or control group. In both groups, five experimental time points, days 1, 3, 7, 14, and 21, were set. After the rats were sacrificed at each time point, the spleen was removed and the natural killer(NK)cell ratio(CD3-/CD161+)in splenic lymphocytes were compared by flow cytometry.<br>　The NK cell ratio of the day 1 group within the mild hypoxia group was significantly higher compared to that of the control group(P<0.05). Moreover, the NK cell ratio of the mild hypoxia groups indicated were significantly lower than those of the control groups for day 7, 14, and 21(P<0.05).<br>　The exposure to mild hypoxia in growing rats may change the NK cell ratio in the splenic lymphocytes.

収録刊行物

  • ＩＪＯＭＳ

    ＩＪＯＭＳ 14 (4), 67-73, 2016

    日本大学松戸歯学部 口腔科学研究所

参考文献 (27)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ