Serum carboxy-terminal telopeptide of type I collagen levels are associated with carotid atherosclerosis in patients with cardiovascular risk factors
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- Kondo Takeshi
- Department of Hematology, Endocrinology & Metabolism Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan
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- Endo Itsuro
- Department of Hematology, Endocrinology & Metabolism Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan
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- Aihara Ken-ichi
- Department of Hematology, Endocrinology & Metabolism Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan
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- Onishi Yukiyo
- Department of Hematology, Endocrinology & Metabolism Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan
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- Dong Bingzi
- Department of Hematology, Endocrinology & Metabolism Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan
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- Ohguro Yukari
- Department of Hematology, Endocrinology & Metabolism Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan
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- Kurahashi Kiyoe
- Department of Hematology, Endocrinology & Metabolism Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan
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- Yoshida Sumiko
- Department of Hematology, Endocrinology & Metabolism Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan
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- Fujinaka Yuichi
- Department of Internal Medicine, Local Incorporated Administrative Agency, Tokushima Prefecture Naruto Hospital, Naruto 772-0001, Japan
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- Kuroda Akio
- Diabetes Therapeutics and Research Center, Tokushima University, Tokushima 770-8503, Japan
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- Matsuhisa Munehide
- Diabetes Therapeutics and Research Center, Tokushima University, Tokushima 770-8503, Japan
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- Fukumoto Seiji
- Fujii Memorial Institute of Medical Sciences, Tokushima University, Tokushima 770-8503, Japan
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- Matsumoto Toshio
- Fujii Memorial Institute of Medical Sciences, Tokushima University, Tokushima 770-8503, Japan
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- Abe Masahiro
- Department of Hematology, Endocrinology & Metabolism Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan
抄録
Carboxy-terminal telopeptide of type I collagen (ICTP) is generated through matrix metalloproteinase (MMP)-dependent type I collagen digestion, and has been widely utilized as a biomarker for bone turnover. The fact that atherosclerotic lesions are rich in both type I collagen and MMP-producing macrophages led to the hypothesis that serum ICTP concentrations may serve as a non-invasive clinical biomarker for atherosclerosis. Therefore, the association of serum ICTP concentrations with the maximum intima-media thickness (IMT) of carotid arteries, a surrogate index of systemic atherosclerosis, or brachial-ankle pulse wave velocity (baPWV) in patients with atherosclerotic risk factors was evaluated. A total of 52 male and 65 female (mean age: 62.8 yrs) patients without renal failure, malignancies or bone diseases known to affect serum ICTP concentrations were recruited. Patients with max IMTs ≥1.1 mm showed significantly higher serum ICTP concentrations compared with patients with max IMTs <1.1 mm (3.33 ± 0.97 vs 2.82 ± 0.65 ng/mL, p<0.05). Serum ICTP concentration was also positively correlated with max IMT (p<0.001) or baPWV values (p<0.05). Multivariate analyses also revealed that serum ICTP concentrations were correlated with max IMT (p<0.001; 95% CI 0.200 to 0.454). These results suggest that serum ICTP concentrations can be used as a non-invasive biomarker for systemic atherosclerosis.
収録刊行物
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- Endocrine Journal
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Endocrine Journal 63 (4), 397-404, 2016
一般社団法人 日本内分泌学会