<b>3,5,6,7,8,3’,4’-Heptamethoxyflavone reduces interleukin-4 production in the spleen cells of </b><b>mice </b>
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- NAKAJIMA Mitsunari
- Department of Pharmaceutical Pharmacology, School of Clinical Pharmacy, College of Pharmaceutical Sciences, Matsuyama University
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- OGAWA Minetaro
- Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University
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- AMAKURA Yoshiaki
- Department of Pharmacognosy, College of Pharmaceutical Sciences, Matsuyama University
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- YOSHIMURA Morio
- Department of Pharmacognosy, College of Pharmaceutical Sciences, Matsuyama University
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- OKUYAMA Satoshi
- Department of Pharmaceutical Pharmacology, School of Clinical Pharmacy, College of Pharmaceutical Sciences, Matsuyama University
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- FURUKAWA Yoshiko
- Department of Pharmaceutical Pharmacology, School of Clinical Pharmacy, College of Pharmaceutical Sciences, Matsuyama University
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抄録
In our previous studies, we reported anti-inflammatory functions of 3,5,6,7,8,3’,4’-heptamethoxyflavone (HMF), which is a polymethoxyflavone rich in various citrus fruits. Here, we investigated the immunomodulatory function of HMF in mice. HMF administration (50 mg/kg, i.p., 2 times/week) tended to reduce the production of antigen-specific IgE induced by ovalbumin in combination with aluminum hydroxide gel. Fluorescence-activated cell sorting analysis revealed the reduction of interleukin-4+CD4+ spleen cells and sustained presence of interferon-γ+CD4+ spleen cells in mice administered HMF, whereas the ratio of CD4+CD8− versus CD4−CD8+ spleen cells was not affected. Interleukin-4 release from CD3/CD28-stimulated spleen cells of mice administered HMF was reduced, whereas interferon-γ release was not affected. These results suggest that HMF has an immunomodulatory function via reduced interleukin-4 expression.
収録刊行物
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- Biomedical Research
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Biomedical Research 37 (2), 95-99, 2016
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