口腔扁平上皮癌の原発巣再発症例の検討

  • 山田 慎一
    長崎大学大学院医歯薬学総合研究科口腔腫瘍治療学分野 信州大学医学部歯科口腔外科学教室
  • 柳本 惣市
    長崎大学大学院医歯薬学総合研究科口腔腫瘍治療学分野
  • 高橋 英哲
    長崎大学大学院医歯薬学総合研究科口腔腫瘍治療学分野
  • 鳴瀬 智史
    長崎大学大学院医歯薬学総合研究科口腔腫瘍治療学分野
  • 白石 剛士
    長崎大学大学院医歯薬学総合研究科顎・口腔再生外科学分野
  • 池田 久住
    長崎大学大学院医歯薬学総合研究科顎・口腔再生外科学分野
  • 朝比奈 泉
    長崎大学大学院医歯薬学総合研究科顎・口腔再生外科学分野
  • 梅田 正博
    長崎大学大学院医歯薬学総合研究科顎・口腔再生外科学分野

書誌事項

タイトル別名
  • Evaluation of Local Recurrence of Oral Squamous Cell Carcinoma

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Among 321 cases with oral squamous cell carcinoma (OSCC) from 2001 to 2011 in the Department of Oral and Maxillofacial Surgery, Nagasaki University Hospital, 221 cases were treated with curative intent, and local recurrence was observed in 34 (15.4%) patients. The average time to local recurrence after initial treatment was 11.3 months. The 5-year overall survival rate of the patients with local recurrence was 48.7%. In this study, univariate analysis revealed that the prognosis of salvage surgery of local recurrence in OSCC patients might be associated with neoadjuvant chemotherapy (P<0.01), recurrence interval (P<0.05), recurrence site (P<0.01), and postoperative adjuvant therapy (P<0.01). Multivariate analysis revealed that the independent prognostic factor of salvage surgery for recurrence in OSCC patients might be recurrence interval (P<0.05), and that NAC and recurrence site tended to be poor prognostic factors of salvage surgery, but there was no significant difference, respectively. It was suggested that the first surgery is very important for a good prognosis in OSCC patients.

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