頭頸部癌の化学放射線療法に伴う口腔粘膜炎対策としてのポラプレジンク含嗽薬の効果

• 小林 敦

  岐阜市民病院歯科口腔外科

書誌事項

タイトル別名

• Effect of Polaprezinc Gargle on Oral Mucositis Caused by Chemoradiotherapy of Head and Neck Cancer

抄録

In recent years, the usefulness of polaprezinc for oral mucositis has been reported. Generally, surgical treatment, chemotherapy, and radiation therapy together or alone are used for cancer treatment. Oral mucositis occurs as a harmful phenomenon in almost 100％ of cases, and the combination of radiation and chemotherapy is accompanied by intense sharp pain and bleeding. We used sodium alginate and solcoseryl to treat oral mucositis, but these were not sufficiently effective in many cases and the treatment had to be stopped. Polaprezinc provides an antioxidant action, mucous membrane protection, wound healing promotion, and is reported to be effective for oral mucositis. We considered that administration of the drug through the oral cavity and oral mucosa by gargling rather than internal administration facilitated direct contact with the drug, and we applied this method in eight chemoradiotherapy head and neck cancer patients. We report a summary of these eight cases in which treatment did not need to be stopped due to oral mucositis by using polaprezinc gargle.

収録刊行物

• 日本口腔診断学会雑誌

  日本口腔診断学会雑誌 29 (1), 8-12, 2016

  日本口腔診断学会

キーワード

• ポラプレジンク
• 口腔粘膜炎
• 頭頸部癌
• 化学放射線療法

詳細情報

• CRID: 1390001205737786880
• NII論文ID: 130005148374
• DOI: 10.15214/jsodom.29.8
• ISSN: 21882843
• ISSN: 09149694
• Web Site: https://www.jstage.jst.go.jp/article/jsodom/29/1/29_29.8/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2016239710
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可