Farnesol-Induced Disruption of the Staphylococcus aureus Cytoplasmic Membrane

• Inoue Yoshihiro

  Showa Pharmaceutical University

• Togashi Naoko

  Showa Pharmaceutical University

• Hamashima Hajime

  Showa Pharmaceutical University

書誌事項

タイトル別名

• Farnesol-Induced Disruption of the <i>Staphylococcus aureus</i> Cytoplasmic Membrane

抄録

Farnesol, a sesquiterpene alcohol with an aliphatic carbon chain, inhibited the growth of Staphylococcus aureus and induced the leakage of potassium ions. We investigated the action of farnesol on the cytoplasmic membrane of S. aureus. No ion channels that would account for the loss of potassium ions were detected. Electron paramagnetic resonance measurements suggested that farnesol proceeds into the cytoplasmic membrane of S. aureus cells, where it induces the disordering and eventual disruption of the cytoplasmic membrane. This was supported by the result that the effects of farnesol decreased by the addition of carotenoid which was the stabilizing reagent for the lipid bilayer.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 39 (5), 653-656, 2016

  公益社団法人 日本薬学会

キーワード

• farnesol
• cell membrane disordering
• <i>Staphylococcus aureus</i>

詳細情報

• CRID: 1390282679609064064
• NII論文ID: 130005149268
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.b15-00416
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 027269844
• PubMed: 27150138
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I027269844
• Web Site: https://www.jstage.jst.go.jp/article/bpb/39/5/39_b15-00416/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2017000444
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可