Histopathology of a wavy medaka

• Irie Kota

  Biological Research Laboratories, Nissan Chemical Industries, Ltd., 1470 Shiraoka, Shiraoka, Saitama 349-0294, Japan

• Kuroda Yusuke

  Biological Research Laboratories, Nissan Chemical Industries, Ltd., 1470 Shiraoka, Shiraoka, Saitama 349-0294, Japan

• Mimori Norihiko

  Biological Research Laboratories, Nissan Chemical Industries, Ltd., 1470 Shiraoka, Shiraoka, Saitama 349-0294, Japan

• Hayashi Seigo

  Biological Research Laboratories, Nissan Chemical Industries, Ltd., 1470 Shiraoka, Shiraoka, Saitama 349-0294, Japan

• Abe Masayoshi

  Biological Research Laboratories, Nissan Chemical Industries, Ltd., 1470 Shiraoka, Shiraoka, Saitama 349-0294, Japan

• Tsuji Naho

  Biological Research Laboratories, Nissan Chemical Industries, Ltd., 1470 Shiraoka, Shiraoka, Saitama 349-0294, Japan

• Sugiyama Akihiko

  Department of Veterinary Laboratory Medicine, School of Veterinary Medicine, Faculty of Agriculture, Tottori University Biological Research Laboratories, 4-101 Minami, Koyama, Tottori 680-8550, Japan

• Furukawa Satoshi

  Biological Research Laboratories, Nissan Chemical Industries, Ltd., 1470 Shiraoka, Shiraoka, Saitama 349-0294, Japan

抄録

Wavy medakas are medakas that exhibit spinal curvature characterized by dorsoventrally curved vertebrae. We found a spontaneous wavy medaka in our experimental stock and subjected it to a histopathological examination. Macroscopically, the wavy medaka’s spine formed an M shape, and its vertebrae displayed a dorsoventral curvature that started at the third vertebral bone. Microscopically, the vertebral cavities were filled with fibrous tissue, which was similar to that seen in the central parts of the intervertebral discs of a normal medaka. The vertebral joints were composed of vacuolated notochord cells without intervertebral disc formation. These changes were also observed in the caudal region, which exhibited less curvature. In the normal medaka, the intervertebral discs form via the regression of the notochord that plays a key role in the development of vertebrae and disc formation. We concluded that notochordal subinvolution had induced intervertebral disc dysplasia, leading to lordokyphosis, in the wavy medaka.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃ　Ｐａｔｈｏｌｏｇｙ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃ　Ｐａｔｈｏｌｏｇｙ 29 (2), 115-118, 2016

  日本毒性病理学会

キーワード

• intervertebral disc
• lordokyphosis
• notochord
• spinal curvature
• wavy medaka

詳細情報

• CRID: 1390001204416370816
• NII論文ID: 130005151003
• NII書誌ID: AN10232280
• DOI: 10.1293/tox.2015-0070
• ISSN: 1881915X
• ISSN: 09149198
• NDL書誌ID: 027347326
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I027347326
• Web Site: https://www.jstage.jst.go.jp/article/tox/29/2/29_2015-0070/_pdf
• 本文言語コード: en
• データソース種別:
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  • NDL
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  • CiNii Articles
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