胃crystal-storing histiocytosisの1例 A case of gastric crystal-storing histiocytosis

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54歳男性.病変は,上部消化管内視鏡検査にて胃角部大彎に25mmの褪色領域として認められた.組織学的に細胞質内に好酸性物質をともなう組織球の集簇が認められ,組織球は免疫組織化学的にCD68(+),IgG(+),κ鎖(+)であった.以上により,IgG-κ型免疫グロブリンを貪食した組織球で構成された,極めてまれな胃crystal-storing histiocytosisと診断された.

A 54-year-old male patient underwent upper gastrointestinal endoscopy, which revealed a 25-mm brown region in the angular section of the greater curvature of the stomach. The region was histologically determined to be gastric mucosa with an accumulation of histiocytes containing eosinophilic substances in the cytoplasm and chronic inflammatory cell infiltration. Histiocytes were immunohistologically positive for CD68, IgG, and κ. Based on these findings, the patient was diagnosed with gastric crystal-storing histiocytosis comprised of histiocytes phagocytosing IgG-κ-type immunoglobulin. This is a rare disease of which there have been no previous reports that included long-term follow-up. Here, we report the case with a literature review.

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  • 日本消化器病学会雑誌

    日本消化器病学会雑誌 113(6), 968-974, 2016

    一般財団法人 日本消化器病学会

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