In Vitro Transformation of Chlorinated Parabens by the Liver S9 Fraction : Kinetics, Metabolite Identification, and Aryl Hydrocarbon Receptor Agonist Activity

DOI Web Site Web Site PubMed 被引用文献1件 参考文献19件
  • Terasaki Masanori
    Department of Environmental Sciences, Faculty of Humanities and Social Sciences, Iwate University Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka
  • Wada Takeshi
    Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka
  • Nagashima Satoshi
    Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka
  • Makino Masakazu
    Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka
  • Yasukawa Hiro
    Academic Group of Applied Life Sciences, Iwate University

書誌事項

タイトル別名
  • <i>In Vitro</i> Transformation of Chlorinated Parabens by the Liver S9 Fraction: Kinetics, Metabolite Identification, and Aryl Hydrocarbon Receptor Agonist Activity

この論文をさがす

抄録

We investigated the kinetics of in vitro transformation of a dichlorinated propyl paraben (2-propyl 3,5-dichloro-4-hydroxybenzoate; Cl2PP) by the rat liver S9 fraction and assessed the aryl hydrocarbon receptor (AhR) agonist activity of the metabolite products identified in HPLC and GC/MS analysis and by metabolite syntheses. The results indicated that the chlorination of Cl2PP reduced its degradation rate by approximately 40-fold. Two hydroxylated metabolite products showed AhR agonist activity of up to 39% of that of the parent Cl2PP when assessed in a yeast (YCM3) reporter gene assay. The determination of the metabolic properties of paraben bioaccumulation presented here provides further information on the value of risk assessments of chlorinated parabens as a means to ensure human health and environmental safety.

収録刊行物

被引用文献 (1)*注記

もっと見る

参考文献 (19)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ