癌リンパ節転移の蛍光イメージング ～PpIXとPPpの蛍光強度レシオを用いて～

• 原田 義規

• 小泉 範明

• 南川 丈夫

• 松尾 久敬

• 戴 平

• 山岡 禎久

• 高松 哲郎

書誌事項

タイトル別名

• Application of protoporphyrin IX (PpIX)-to-photoprotoporphyrin (PPp) fluorescence ratio to imaging of metastatic gastric cancer in excised lymph nodes

抄録

Fluorescence of protoporphyrin IX (PpIX) is useful for diagnosis of metastatic cancer in lymph nodes. PpIX is selectively accumulated in cancer tissues. However, autofluorescence arising from background tissues is an obstacle for specific detection of PpIX fluorescence. When PpIX is converted to photoprotoporphyrin (PPp) after exposure to light, the fluorescence peak is shifted from 635 nm to 675 nm. Since the shift of the fluorescence peaks is unique in PpIX, the acquisition of the shift is helpful in specific detection of PpIX in tissues possessing autofluorescence. In this study, we sought to develop a method to specifically detect PpIX fluorescence in autofluorescent tissues. The results showed that the method aided in detecting PpIX fluorescence in metastatic gastric carcinoma in resected lymph nodes.

収録刊行物

• 生体医工学

  生体医工学 53 (Supplement), S215_02-S215_02, 2015

  公益社団法人 日本生体医工学会

詳細情報

• CRID: 1390001205266069888
• NII論文ID: 130005163584
• DOI: 10.11239/jsmbe.53.s215_02
• ISSN: 18814379
• ISSN: 1347443X
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可