Historical control background incidence of spontaneous thyroid and parathyroid glands lesions of rats and CD-1 mice used in 104-week carcinogenicity studies

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  • Isobe Kaori
    Charles River Laboratories Edinburgh Ltd., Elphinstone Research Centre, Tranent, East Lothian, EH33 2NE, United Kingdom
  • Mukaratirwa Sydney
    Charles River Laboratories Edinburgh Ltd., Elphinstone Research Centre, Tranent, East Lothian, EH33 2NE, United Kingdom
  • Petterino Claudio
    Charles River Laboratories Edinburgh Ltd., Elphinstone Research Centre, Tranent, East Lothian, EH33 2NE, United Kingdom
  • Bradley Alys
    Charles River Laboratories Edinburgh Ltd., Elphinstone Research Centre, Tranent, East Lothian, EH33 2NE, United Kingdom

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<p> The incidence and range of spontaneous thyroid and parathyroid glands findings were determined in control Han-Wistar and Sprague-Dawley rats, and CD-1 mice from 104-week carcinogenicity studies carried out between 1998 and 2010 at Charles River Edinburgh. In both strains of rats and in CD-1 mice, non-proliferative lesions of the thyroid or parathyroid glands were generally uncommon apart from some findings in CD-1 mice such as ultimobranchial duct/cyst (5.72%), follicular distension/dilatation (3.84%), and cystic follicles (3.53%). In Han-Wistar rats, thyroid proliferative lesions were slightly more frequent in males than in females, but in Sprague-Dawley rats, they were of similar incidence in both sexes. The most common findings overall in Han-Wistar and Sprague-Dawley rats were C-cell hyperplasia (48.11% and 36.56%, respectively) and adenoma (10.87% and 9.52%, respectively), follicular cell hyperplasia (4.21% and 0.91%, respectively) and adenoma (4.32% and 1.36%, respectively). Secondary neoplastic lesions either in thyroid or parathyroid gland were poorly represented.</p>

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