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- Kamiya Chizuko A.
- Department of Perinatology and Gynecology, National Cerebral and Cardiovascular Center
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- Yoshimatsu Jun
- Department of Perinatology and Gynecology, National Cerebral and Cardiovascular Center
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- Ikeda Tomoaki
- Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine
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<p>Peripartum cardiomyopathy (PPCM) is a rare, but life-threatening condition that occurs during the peripartum period in previously healthy women. Although its etiology remains unknown, potential risk factors include hypertensive disorders during pregnancy, such as preeclampsia, advanced maternal age, multiparity, multiple gestation, and African descent. Several cohort studies of PPCM revealed that the prevalence of these risk factors was quite similar. Clinically, approximately 40% of PPCM patients are complicated with hypertensive disorders during pregnancy. Because PPCM is a diagnosis of exclusion, heterogeneity is a common element in its pathogenesis. Recent genetic research has given us new aspects of the disease. PPCM and dilated cardiomyopathy (DCM) share genetic predisposition: 15% of PPCM patients were found to have genetic mutations that have been associated with DCM, and they showed a lower recovery rate. Other basic research using PPCM model mice suggests that predisposition genes related to both hypertensive and cardiac disorders via angiogenic imbalance may explain common elements of hypertensive disorders and PPCM. Furthermore, hypertensive disorders during pregnancy are now found to be a risk factor of not only PPCM, but also cardiomyopathy in the future. Understanding genetic variations allows us to stratify PPCM patients and to guide therapy. (Circ J 2016; 80: 1684–1688)</p>
収録刊行物
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- Circulation Journal
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Circulation Journal 80 (8), 1684-1688, 2016
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390001205106121856
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- NII論文ID
- 130005166084
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- NII書誌ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- NDL書誌ID
- 027499015
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- PubMed
- 27385280
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可