Predictors of Rapid Progression and Clinical Outcome of Asymptomatic Severe Aortic Stenosis
-
- Nishimura Shunsuke
- Department of Cardiology, Tenri Hospital
-
- Izumi Chisato
- Department of Cardiology, Tenri Hospital
-
- Nishiga Masataka
- Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
-
- Amano Masashi
- Department of Cardiology, Tenri Hospital
-
- Imamura Sari
- Department of Cardiology, Tenri Hospital
-
- Onishi Naoaki
- Department of Cardiology, Tenri Hospital
-
- Tamaki Yodo
- Department of Cardiology, Tenri Hospital
-
- Enomoto Soichiro
- Department of Cardiology, Tenri Hospital
-
- Miyake Makoto
- Department of Cardiology, Tenri Hospital
-
- Tamura Toshihiro
- Department of Cardiology, Tenri Hospital
-
- Kondo Hirokazu
- Department of Cardiology, Tenri Hospital
-
- Kaitani Kazuaki
- Department of Cardiology, Tenri Hospital
-
- Nakagawa Yoshihisa
- Department of Cardiology, Tenri Hospital
この論文をさがす
抄録
<p>Background:The optimal timing of aortic valve replacement (AVR) is controversial in patients with asymptomatic severe aortic stenosis (AS) except when very severe. Prediction of progression of severe AS is helpful in deciding on the timing of AVR. The purpose of this study was to clarify the predictors of progression rate and clinical outcomes of severe AS.</p><p>Methods and Results:We retrospectively investigated 140 consecutive patients with asymptomatic severe AS (aortic valve area [AVA], 0.75–1.0 cm2). First-year progression rate and annual progression rate of AVA and of aortic jet velocity (AV-Vel) were calculated. Cardiac events were examined and the predictors of rapid progression and cardiac events were analyzed. The median follow-up period was 36 months. The median annual progression rate was −0.05 cm2/year for AVA and 0.22 m/s/year for AV-Vel. Dyslipidemia, moderate-severe calcification, and first-year AV-Vel progression ≥0.22 m/s/year were independent predictors of cardiac events. Cardiac event-free rate was lower in patients with AV-Vel first-year progression rate ≥0.22 m/s/year than in those with a lower rate. Diabetes and moderate-severe calcification were related to first-year rapid progression.</p><p>Conclusions:The annual progression rate of severe AS was −0.05 cm2/year for AVA and 0.22 m/s/year for AV-Vel. Patients with first-year rapid progression or severely calcified aortic valve should be carefully observed while considering an early operation. (Circ J 2016; 80: 1863–1869)</p>
収録刊行物
-
- Circulation Journal
-
Circulation Journal 80 (8), 1863-1869, 2016
一般社団法人 日本循環器学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282680082833792
-
- NII論文ID
- 130005166085
-
- NII書誌ID
- AA11591968
-
- ISSN
- 13474820
- 13469843
-
- NDL書誌ID
- 027499898
-
- PubMed
- 27334030
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可