ナノ粒子の妊娠期曝露が次世代中枢神経系に及ぼす影響

• 梅澤 雅和

  東京理科大学研究推進機構総合研究院 東京理科大学基礎工学部材料工学科

• 小野田 淳人

  東京理科大学大学院薬学研究科衛生化学研究室

• 武田 健

  東京理科大学研究推進機構総合研究院 東京理科大学大学院薬学研究科衛生化学研究室

書誌事項

タイトル別名

• Developmental Toxicity of Nanoparticles on the Brain
• ナノ リュウシ ノ ニンシンキ バクロ ガ ジセダイ チュウスウ シンケイケイ ニ オヨボス エイキョウ

抄録

 The toxicity of nanoparticles (nanotoxicology) is being investigated to understand both the health impacts of atmospheric ultrafine particles—the size of which is a fraction (<0.1 μm aerodynamic diameter) of that of PM_2.5 (<2.5 μm diameter)—and the safer use of engineered nanomaterials. Developmental toxicity of nanoparticles has been studied since their transfer from pregnant body to fetal circulation and offspring body was first reported. Here we reviewed the developmental toxicity of nanoparticles on the brain, one of the most important organs in maintenance of mental health and high quality of life. Recently the dose- and size-dependency of transplacental nanoparticle transfer to the fetus was reported. It is important to understand both the mechanism of direct effect of nanoparticles transferred to the fetus and offspring and the indirect effect mediated by induction of oxidative stress and inflammation in the pregnant body. Locomotor activity, learning and memory, motor coordination, and social behavior were reported as potential neurobehavioral targets of maternal nanoparticle exposure. Histopathologically, brain perivascular cells, including perivascular macrophages and surrounding astrocytes, have an important role in waste clearance from the brain parenchyma. They are potentially the most sensitive target of maternal exposure to low-dose nanoparticles. Further investigations will show the detailed mechanism of developmental toxicity of nanoparticles and preventive strategies against intended and unintended nanoparticle exposure. This knowledge will contribute to the safer design of nanoparticles through the development of sensitive and quantitative endpoints for prediction of their developmental toxicity.<br>

収録刊行物

• 薬学雑誌

  薬学雑誌 137 (1), 73-78, 2017-01-01

  公益社団法人 日本薬学会

キーワード

• maternal exposure
• nanoparticle
• brain
• developmental neurotoxicity

詳細情報

• CRID: 1390282681103206016
• NII論文ID: 130005180861
• NII書誌ID: AN00284903
• DOI: 10.1248/yakushi.16-00214
• ISSN: 13475231
• ISSN: 00316903
• NDL書誌ID: 027836801
• PubMed: 28049898
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I027836801
• Web Site: https://www.jstage.jst.go.jp/article/yakushi/137/1/137_16-00214/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2017254559
• 本文言語コード: ja
• データソース種別:
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  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可