リバスチグミン貼付剤の投与継続に及ぼすメマンチンの影響<br/>—ロジスティック回帰分析を用いた後方視的研究—

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タイトル別名
  • Influence of Memantine on Continuous Treatment with Rivastigmine Patches<br/>—Retrospective Study Using the Logistic Regression Analysis—
  • リバスチグミン貼付剤の投与継続に及ぼすメマンチンの影響 : ロジスティック回帰分析を用いた後方視的研究
  • リバスチグミン チョウフザイ ノ トウヨ ケイゾク ニ オヨボス メマンチン ノ エイキョウ : ロジスティック カイキ ブンセキ オ モチイタ コウホウ シテキ ケンキュウ
  • Influence of Memantine on Continuous Treatment with Rivastigmine Patches<br/>&mdash;Retrospective Study Using the Logistic Regression Analysis&mdash;

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抄録

 Rivastigmine patches exhibit stable effects when attached once a day, and may reduce Alzheimer's disease (AD) patient's or caregiver's burden. On the other hand, it was reported that adverse events, such as dermal disorder, frequently appeared after the start of rivastigmine administration. We retrospectively investigated medical records in 120 patients with moderate or mild AD in whom rivastigmine administration was started in the Department of Neurology, Fukuoka University Hospital between July 2011 and June 2014 (43 males, 77 females, mean age: 76.9±8.0 years). In 72 patients (60.0%), rivastigmine administration was discontinued within 52 weeks after its start. In 45 of these, it was discontinued before reaching a dose of 18 mg/d which was proven to be effective for AD patients. A primary reason for discontinuation was the appearance or deterioration of adverse events in 64 patients. Of these, 43 complained of dermal disorder, accounting for the highest percentage. To clarify factors influencing the continuous administration of rivastigmine, multivariate analysis was performed in 114 patients meeting criteria. Combination therapy with memantine was extracted as a factor (p=0.008). The results of this study suggest that adherence to combination therapy with rivastigmine and memantine is more favorable than that to monotherapy with rivastigmine.<br>

収録刊行物

  • 薬学雑誌

    薬学雑誌 137 (1), 121-125, 2017

    公益社団法人 日本薬学会

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