A Novel Clerodane Diterpene from Vitex cofassus

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  • Rasyid Faradiba Abdul
    School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University
  • Fukuyoshi Shuichi
    School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University
  • Ando Hirokazu
    School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University
  • Miyake Katsunori
    School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University
  • Atsumi Toshiyuki
    School of Pharmacy, Kyushu University of Health and Welfare
  • Fujie Tetsuo
    Advanced Science Research Center, Kanazawa University
  • Saito Yohei
    School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University
  • Goto Masuo
    UNC Eshelman School of Pharmacy, University of North Carolina
  • Shinya Tomohiro
    School of Pharmacy, Kyushu University of Health and Welfare
  • Mikage Masayuki
    Faculty of Agriculture, Tokyo University of Agriculture
  • Sasaki Yohei
    School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University
  • Nakagawa-Goto Kyoko
    School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University UNC Eshelman School of Pharmacy, University of North Carolina

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  • A Novel Clerodane Diterpene from <i>Vitex cofassus</i>

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<p>New clerodane diterpene, 16-hydroxy-pentandralactone (1) and known diterpene acuminolide (2) were isolated from the methanol extract of Vitex cofassus leaves. The chemical structure and the absolute configuration of 1 were determined by MS, NMR and electron circular dichroism (ECD) experiments. The isolated compounds were evaluated for their antiproliferative activities against a panel of human tumor cell lines, including a multidrug-resistant (MDR) cell line. Both compounds showed potent antiproliferative activities against all the tested cell lines with IC50 values of 5.4–11.4 µM. Their effects on cell viability were also tested using vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cells (HUVECs). Compound 1 inhibited VEGF-stimulated HUVEC proliferation in a dose-dependent manner. Based on these results, compound 1 could be a candidate for antitumor agent and inhibitor of angiogenesis.</p>

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