Biphasic Force-Frequency Relation Predicts Primary Cardiac Events in Patients With Hypertrophic Cardiomyopathy
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- Morimoto Ryota
- Department of Cardiology, Nagoya University Graduate School of Medicine Department of CKD Initiatives Internal Medicine, Nagoya University Graduate School of Medicine
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- Okumura Takahiro
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Bando Yasuko K.
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Fukaya Kenji
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Sawamura Akinori
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Kawase Haruya
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Shimizu Shinya
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Shimazu Shuzo
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Hirashiki Akihiro
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Takeshita Kyosuke
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Murohara Toyoaki
- Department of Cardiology, Nagoya University Graduate School of Medicine
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<p>Background:The force-frequency relation (FFR) is a hemodynamic index of the chronotropic relationship between left ventricular (LV) systolic function (percent change in dP/dtmax) and elevation of heart rate. FFR is a marker of myocardial contractile reserve and follows an upward slope in healthy myocardium [monophasic FFR (MoF)], a pattern that becomes biphasic (BiF) under pathological conditions. However, it remains uncertain whether the FFR determines a patient’s prognosis. We investigated the promising role of the FFR as a predictor of cardiac events in the setting of hypertrophic cardiomyopathy (HCM).</p><p>Methods and Results:A total of 113 consecutive patients with HCM (New York Heart Association (NYHA) class I–II) were retrospectively evaluated; 27 (23.9%) had a BiF pattern and they experienced a higher incidence of cardiac events compared with those showing an MoF pattern (median follow-up, 4.7 years; P<0.001). Furthermore, Cox proportional hazard regression analysis revealed that the LV end-diastolic volume index (hazard ratio: 1.051, P=0.014) and BiF pattern (hazard ratio: 15.260, P=0.001) were independent predictors of primary cardiac events. Interestingly, abnormal reductions in myocardial regulatory molecules related to contractility (SERCA2α) were observed exclusively in the patients exhibiting a BiF pattern.</p><p>Conclusions:The FFR reflects latent myocardial abnormalities and predicts cardiac events in the setting of HCM, even during the asymptomatic stages of the disease.</p>
収録刊行物
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- Circulation Journal
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Circulation Journal 81 (3), 368-375, 2017
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390282680085588352
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- NII論文ID
- 130005243014
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- NII書誌ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- NDL書誌ID
- 028001036
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- PubMed
- 28025461
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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