頭部PET/CT 検査におけるCT とPET との位置ずれが再構成画像に及ぼす影響についての検討

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  • The Effects of Misalignment between PET and CT Scans on Brain PET Study Using CT-based Attenuation Correction: A Phantom Study
  • トウブ PET/CT ケンサ ニ オケル CT ト PET ト ノ イチズレ ガ サイコウセイ ガゾウ ニ オヨボス エイキョウ ニ ツイテ ノ ケントウ

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<p>Purpose: The aim of this study was to evaluate the effects of inaccurate attenuation correction due to the misalignment between the computed tomography (CT)-based μ-map and the positron emission tomography (PET) data on a brain PET. Methods: CT and PET scans were performed on a 3-dimension (3D) brain phantom, in which the grey matter region was filled with 18F-fluorodeoxyglucose (18F-FDG), and the skull region was filled with/without the bone-equivalent solution. The shifted PET images relative to the CT image were generated by the software-based translation of PET data in the cephalad/caudal and right directions, with a magnitude of the shift up to 30 mm and a step size of 5 mm. The regions of interest (ROIs) were drawn on the areas of the temporal lobes, parietal lobes, thalami, and cerebellums in the no-shifted image (reference). For each ROI, the radioactivity concentrations in the shifted images were compared with those of the reference. Results: The errors in the radioactivity concentrations were increased with the increasing magnitude of the shift in all brain regions except for thalamus. For a 5 mm shift in the right direction, ± 10% errors were observed in the left/right temporal lobes. The accuracy of the radioactivity concentration in the temporal lobe was very sensitive to misalignment in the right directions. Conclusion: The misalignment between CT-based μ-map and PET data had larger effects on the surface regions of the brain rather than on deep brain structures.</p>

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