Adiponectin plays a role in energy metabolism for musk secretion in scent glands of muskrats (<i>Ondatra zibethicus</i>)
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- Zhang Tianxiang
- College of Nature Conservation, Beijing Forestry University, Beijing 100083, People’s Republic of China
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- Li Weixuan
- College of Nature Conservation, Beijing Forestry University, Beijing 100083, People’s Republic of China Zhonshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, People’s Republic of China
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- Qi Lei
- College of Nature Conservation, Beijing Forestry University, Beijing 100083, People’s Republic of China
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- Fan Mengyuan
- College of Nature Conservation, Beijing Forestry University, Beijing 100083, People’s Republic of China
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- Shen Jiachen
- College of Biological Science and Technology, Beijing Forestry University, Beijing 100083, People’s Republic of China
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- Wang Yihua
- College of Nature Conservation, Beijing Forestry University, Beijing 100083, People’s Republic of China
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- Wang Wenxia
- College of Nature Conservation, Beijing Forestry University, Beijing 100083, People’s Republic of China
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- Hu Xiaolong
- College of Nature Conservation, Beijing Forestry University, Beijing 100083, People’s Republic of China
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- Cai Ruibo
- College of Nature Conservation, Beijing Forestry University, Beijing 100083, People’s Republic of China
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- Zhou Ran
- College of Nature Conservation, Beijing Forestry University, Beijing 100083, People’s Republic of China
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- Wei Yuting
- College of Nature Conservation, Beijing Forestry University, Beijing 100083, People’s Republic of China
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- Zhou Juntong
- College of Nature Conservation, Beijing Forestry University, Beijing 100083, People’s Republic of China
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- Yang Shuang
- College of Nature Conservation, Beijing Forestry University, Beijing 100083, People’s Republic of China
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- Hu Defu
- College of Nature Conservation, Beijing Forestry University, Beijing 100083, People’s Republic of China
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- Liu Shuqiang
- College of Nature Conservation, Beijing Forestry University, Beijing 100083, People’s Republic of China
抄録
Adult male muskrats (Ondatra zibethicus) secret musk from their scent glands to attract females for seasonal mating. The goal of the present study was to investigate whether the changes in energy metabolism related to musk secretion during the breeding and non-breeding seasons are mediated by adiponectin. We found that the secretion of musk during the breeding season was markedly greater than that during the non-breeding season. The serum adiponectin concentration measured using an ELISA kit was higher during the breeding season than during the non-breeding season. Glandular cells, interstitial cells, epithelial cells and glandular cavities were detected in scent glands using histological methods. Immunohistochemical methods were used to show that AMP-activated protein kinase-gamma-1 (AMPKG1), and glucose transporter 1 (GLUT1) were more strongly expressed in glandular cells during the breeding season than the non-breeding season, whereas the immunoreactivity for acetyl-CoA carboxylase 1 (ACC1) was stronger during the non-breeding season. Consistent with these qualitative results, RNA-Seq analysis indicated that the expression of AdipoR1 mRNA was not significantly different during the two seasons. However, AMPKG1 and GLUT1 mRNA levels were higher in scent glands during the breeding season than during the non-breeding season, whereas ACC1 mRNA levels notably decreased during the breeding season. These results suggest that greater musk secretion requires additional energy, which may be provided by an adiponectin-mediated increase in β-oxidation and glucose absorption.
収録刊行物
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- Endocrine Journal
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Endocrine Journal 63 (7), 633-641, 2016
一般社団法人 日本内分泌学会
