Rho-kinase inhibitor decreased pulmonary artery resistance, whereas increased compliance in a rat model of pulmonary hypertension

• NISHIKAWA Takuya

  Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences

• SAKU Keita

  Center for Disruptive Cardiovascular Medicine, Kyushu University

• SAKAMOTO Takafumi

  Depertment of Cardiovascular Medicine, Kyushu University

• OGA Yasuhiro

  Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences

• TOHYAMA Takeshi

  Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences

• KISHI Takuya

  Center for Disruptive Cardiovascular Medicine, Kyushu University

• SUNAGAWA Kenji

  Center for Disruptive Cardiovascular Medicine, Kyushu University

抄録

Although the dynamic mechanical properties such as arterial compliance (C) have been shown to predict increased mortality in patients with pulmonary arterial hypertension (PAH), a simple static index, i.e., pulmonary arterial resistance (R) has been exclusively used in clinical settings. We examined how a Rho-kinase inhibitor, fasudil, that is known to suppress vasoconstriction, affects pulmonary artery input impedance (Z) in Sugen/Hypoxia (SuHx) PAH in rats. We measured Z before PAH induction (Normal), and re-measured before/after fasudil injection (10 mg/kg) (PAH/Fasudil). PAH increased R while Fasudil decreased R (Normal: 16.3±2.6, PAH: 56.5±6.9, Fasudil: 39.9±5.2 mmHg/ml/sec, p<0.01). In contrast, PAH decreased C while Fasudil increased C (Normal: 3.6±0.6, PAH: 1.8±0.4, Fasudil: 2.5±0.8×10³ ml/mmHg, p<0.01). We conclude that the pulmonary arterial impedance may serve as a new tool in analyzing vascular mechanics to assess the severity or the drug efficacy in PAH patients.

収録刊行物

• 生体医工学

  生体医工学 54Annual (Proc), 1T6-2-2-1-1T6-2-2-2, 2016

  公益社団法人 日本生体医工学会

キーワード

• Pulmonary arterial hypertension
• impedance
• pulmonary circulation
• Rho-kinase inhibitor

詳細情報

• CRID: 1390001205270464640
• NII論文ID: 130005285484
• DOI: 10.11239/jsmbe.54annual.1t6-2-2-1
• ISSN: 18814379
• ISSN: 1347443X
• 本文言語コード: en
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可