PSLナノ粒子の細胞毒性に及ぼす酵母エキスの影響とナノ粒子－細胞間付着力のAFM測定

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タイトル別名
  • Influence of Yeast Extract on the Cytotoxicity of PSL Nanoparticles and Adhesion Force Measurement between a Nanoparticle and a Cell Using AFM
  • PSLナノ粒子の細胞毒性に及ぼす酵母エキスの影響とナノ粒子 : 細胞間付着力の測定
  • PSL ナノ リュウシ ノ サイボウ ドクセイ ニ オヨボス コウボ エキス ノ エイキョウ ト ナノ リュウシ : サイボウ カン フチャクリョク ノ ソクテイ
  • Influence of yeast extract on the cytotoxicity of PSL nanoparticles and adhesion force measurement between a nanoparticle and a cell using AFM (in Japanese)

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<p>The effect of yeast extract on the cytotoxicity and the colloidal behavior of positively charged polystyrene latex （PSL） nanoparticles （NPs） toward yeast cells were investigated. Confocal observation revealed that the cells were alive and the NPs were dispersed when adding the yeast extract into 5 mM NaCl, results that were quite different from the toxicological effects in 5 mM NaCl without the yeast extract. This is because the negatively charged organic molecules in the yeast extract adhered on the NPs, leading that the NP surface changed negative. Additionally, the PSL NPs showed no toxicity when the yeast cells were incubated in the perfect media （yeast extract and glucose）. These results suggest that the PSL NPs display little or no toxicity toward the environmental microorganisms. Nanocolloidal probe atomic force microscopy revealed that the adhesion forces between the PSL NP and the yeast cell drastically decrease when adding the yeast extract.</p><p></p>

収録刊行物

  • 粉体工学会誌

    粉体工学会誌 53 (12), 762-767, 2016

    一般社団法人 粉体工学会

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