Antibiotic-induced immediate type hypersensitivity is a risk factor for positive allergy skin tests for neuromuscular blocking agents
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- Hagau Natalia
- Department of Anaesthesia and Intensive Care II, University of Medicine and Pharmacy “Iuliu Hatieganu”
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- Gherman Nadia
- Department of Allergology and Immunology, University of Medicine and Pharmacy “Iuliu Hatieganu”
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- Cocis Mihaela
- Department of Anaesthesia and Intensive Care II, University of Medicine and Pharmacy “Iuliu Hatieganu”
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- Petrisor Cristina
- Department of Anaesthesia and Intensive Care II, University of Medicine and Pharmacy “Iuliu Hatieganu”
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Background: Skin tests for neuromuscular blocking agents (NMBAs) are not currently recommended for the general population undergoing general anaesthesia. In a previous study we have reported a high incidence of positive allergy tests for NMBAs in patients with a positive history of non-anaesthetic drug allergy, a larger prospective study being needed to confirm those preliminary results. The objective of this study was to compare the skin tests results for patients with a positive history of antibiotic-induced immediate type hypersensitivity reactions to those of controls without drug allergies. Methods: Ninety eight patients with previous antibiotic hypersensitivity and 72 controls were prospectively included. Skin tests were performed for atracurium, pancuronium, rocuronium, and suxamethonium. Results: We found 65 positive skin tests from the 392 tests performed in patients with a positive history of antibiotic hypersensitivity (1 6.58%) and 23 positive skin tests from the 288 performed in controls (7.98%), the two incidences showing significant statistical difference (p = 0.0011). The relative risk for having a positive skin test for NMBAs for patients versus controls was 1.77 (1.15-2.76). For atracurium, skin tests were more often positive in patients with a positive history of antibiotic hypersensitivity versus controls (p = 0.02). For pancuronium, rocuronium and suxamethonium the statistical difference was not attained (p-values 0.08 for pancuronium, 0.23 for rocuronium, and 0.26 for suxamethonium). Conclusions: Patients with a positive history of antibiotic hypersensitivity seem to have a higher incidence of positive skin tests for NMBAs. They might represent a group at higher risk for developing intraoperative anaphylaxis compared to the general population.
収録刊行物
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- Allergology International
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Allergology International 65 (1), 52-55, 2016
一般社団法人日本アレルギー学会
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詳細情報 詳細情報について
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- CRID
- 1390282679609151744
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- NII論文ID
- 130005290429
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- ISSN
- 14401592
- 13238930
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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