Inhibitory Activities of Antioxidant Flavonoids from Tamarix gallica on Amyloid Aggregation Related to Alzheimer's and Type 2 Diabetes Diseases

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  • Ben Hmidene Asma
    Graduate School of Life and Environmental Sciences, University of Tsukuba
  • Hanaki Mizuho
    Graduate School of Biostudies, Kyoto University
  • Murakami Kazuma
    Graduate School of Biostudies, Kyoto University
  • Irie Kazuhiro
    Graduate School of Biostudies, Kyoto University
  • Isoda Hiroko
    Alliance for Research on North Africa (ARENA), University of Tsukuba Faculty of Life and Environmental Sciences, University of Tsukuba
  • Shigemori Hideyuki
    Faculty of Life and Environmental Sciences, University of Tsukuba

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  • Inhibitory Activities of Antioxidant Flavonoids from <i>Tamarix gallica</i> on Amyloid Aggregation Related to Alzheimer’s and Type 2 Diabetes Diseases

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<p>The prevention of amyloid aggregation is promising for the treatment of age-related diseases such as Alzheimer’s (AD) and type 2 diabetes (T2D). Ten antioxidant flavonoids isolated from the medicinal halophyte Tamarix gallica were tested for their amyloid aggregation inhibition potential. Glucuronosylated flavonoids show relatively strong inhibitory activity of Amyloid β (Aβ) and human islet amyloid polypeptide (hIAPP) aggregation compared to their aglycone analogs. Structure–activity relationship of the flavonoids suggests that the catechol moiety is important for amyloid aggregation inhibition, while the methylation of the carboxyl group in the glucuronide moiety and of the hydroxyl group in the aglycone flavonoids decreased it.</p>

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