Pharmacokinetic studies of the recombinant chicken interferon-α in broiler chickens
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- ZHAO Jun
- Wuhu Overseas Students Pioneer Park, Wuhu, Anhui Province, 241000, China Department of Microbiology, Anhui Medical University, Hefei, Anhui Province, 230032, China
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- YU Hai-Yang
- Department of Microbiology, Anhui Medical University, Hefei, Anhui Province, 230032, China
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- ZHANG Jun-Ling
- Department of Microbiology, Anhui Medical University, Hefei, Anhui Province, 230032, China
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- WANG Xing-Man
- Department of Microbiology, Anhui Medical University, Hefei, Anhui Province, 230032, China
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- LI Jin-Pei
- Department of Microbiology, Anhui Medical University, Hefei, Anhui Province, 230032, China
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- HU Tao
- Department of Microbiology, Anhui Medical University, Hefei, Anhui Province, 230032, China
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- HU Yong
- Department of Microbiology, Anhui Medical University, Hefei, Anhui Province, 230032, China
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- WANG Ming-Li
- Wuhu Overseas Students Pioneer Park, Wuhu, Anhui Province, 241000, China Department of Microbiology, Anhui Medical University, Hefei, Anhui Province, 230032, China
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- SHEN Yong-Zhou
- Anhui JiuChuan Biotech Co., Ltd., Wuhu, Anhui Province, 241007, China
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- XU Jing-Dong
- Anhui JiuChuan Biotech Co., Ltd., Wuhu, Anhui Province, 241007, China
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- HAN Guo-Xiang
- Anhui JiuChuan Biotech Co., Ltd., Wuhu, Anhui Province, 241007, China
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- CHEN Jason
- Department of Microbiology, Anhui Medical University, Hefei, Anhui Province, 230032, China Department of Pathology & Cell Biology, Columbia University, New York 10032, U.S.A.
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抄録
<p>In this study, 24 male and female broiler chickens at 30-day-old were divided into three groups with 8 animals in each group. The animals were administered with recombinant chicken interferon-α (rChIFN-α) at a dose of 1.0 × 106 IU/kg intravenously, intramuscularly or subcutaneously, respectively. Serum samples were collected at different time points post administration, and the titers of rChIFN-α in the blood were determined by cytopathic effect inhibition assay. The results showed that the pharmacokinetic characteristics of rChIFN-α by intramuscular injection and subcutaneous injection were fitted to one compartment open model, and the Tmax was 3.21 ± 0.79 hr and 3.95 ± 0.85 hr, respectively, and the elimination half-life (T1/2) was 6.20 ± 2.77 hr and 5.03 ± 3.70 hr, respectively. In contrast, the pharmacokinetics of rChIFN-α via intravenous injection was in line with the open model of two-compartment and was eliminated in the first order, and the elimination half-life (T1/2) was 4.61 ± 0.84 hr. In addition, compared with those in the intravenous group and the subcutaneous group, the bioavailability of rChIFN-α in the intramuscular group was 82.80%. In conclusion, rChIFN-α was rapidly absorbed and slowly eliminated after intramuscular administration of single dose of rChIFN-α aqueous formulations. Thus, rChIFN-α can be used as a commonly-used therapeutic agent.</p>
収録刊行物
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- Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｖｅｔｅｒｉｎａｒｙ Ｍｅｄｉｃａｌ Ｓｃｉｅｎｃｅ
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Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｖｅｔｅｒｉｎａｒｙ Ｍｅｄｉｃａｌ Ｓｃｉｅｎｃｅ 79 (2), 314-319, 2017
公益社団法人 日本獣医学会