The prognostic factor of the patients with extracapsular spread for cervical lymph node metastasis of oral squamous cell carcinomas
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- Uzawa Narikazu
- Department of Maxillofacial Surgery, Division of Maxillofacial and Neck Reconstruction, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
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- Morita Takuma
- Department of Maxillofacial Surgery, Division of Maxillofacial and Neck Reconstruction, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
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- Hoshi Reiko
- Department of Maxillofacial Surgery, Division of Maxillofacial and Neck Reconstruction, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
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- Akatsu Chie
- Department of Maxillofacial Surgery, Division of Maxillofacial and Neck Reconstruction, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
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- Michi Yasuyuki
- Department of Maxillofacial Surgery, Division of Maxillofacial and Neck Reconstruction, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
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- Ohyama Yoshio
- Department of Maxillofacial Surgery, Division of Maxillofacial and Neck Reconstruction, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
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- Sumino Jun
- Department of Maxillofacial Surgery, Division of Maxillofacial and Neck Reconstruction, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
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- Myo Kunihiro
- Department of Maxillofacial Surgery, Division of Maxillofacial and Neck Reconstruction, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
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- Yamashiro Masashi
- Department of Maxillofacial Surgery, Division of Maxillofacial and Neck Reconstruction, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University Dentistry & Oral Surgery, NTT Medical Center Tokyo
Bibliographic Information
- Other Title
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- 口腔癌頸部リンパ節転移被膜外浸潤陽性症例の予後因子に関する検討
Abstract
Extracapsular spread (ECS) of metastatic lymph node in oral cancer is the most significant prognostic predictor of poor treatment outcome. However, only a few reports on prognostic indicators in ECS positive cases have been published. The purpose of this study was to determine the prognostic factors of oral squamous cell carcinoma (OSCC) with ECS in metastatic lymph nodes. In this study, the cases of 77 patients with primary OSCC, who attended our hospital from 2008 to 2013 and had at least one pathologically metastatic node with ECS, were reviewed. Patients with primary recurrence during follow up were excluded from the present study. Univariate analyses revealed that many kinds of cervical metastatic factor, including number of ECS positive lymph nodes, were significantly associated with recurrence and poor outcome. Moreover, multivariate analyses indicated that the number of ECS positive metastatic lymph nodes is the only significant factor predicting regional recurrence and poor outcome. In conclusion, the number of ECS positive lymph nodes is the most important prognostic indicator for OSCC with ECS in metastatic lymph nodes. Thus, classification of ECS status using the number of ECS positive lymph nodes may be useful for further prediction of poorer prognosis in OSCC cases. However, standardization of ECS diagnosis and a larger multicenter prospective study for refining the present finding are required.
Journal
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- Toukeibu Gan
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Toukeibu Gan 42 (4), 400-405, 2016
Japan Society for Head and Neck Cancer
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Details 詳細情報について
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- CRID
- 1390001205221150208
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- NII Article ID
- 130005395150
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- ISSN
- 18818382
- 13495747
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed