金属曝露がもたらすエピジェネティックな変化とその分子機構

• 木村 朋紀

  摂南大学理工学部生命科学科

書誌事項

タイトル別名

• Metal-mediated Epigenetic Regulation of Gene Expression
• Symposium Review 金属曝露がもたらすエピジェネティックな変化とその分子機構
• Symposium Review キンゾク バクロ ガ モタラス エピジェネティック ナ ヘンカ ト ソノ ブンシ キコウ

抄録

 Epigenetics is the study of heritable changes in gene expression that occur without alterations in the DNA sequence. Several studies have shown that environmental chemicals can alter epigenetic modifications, including histone modifications and DNA methylation. Environmental chemicals may show toxic effects via epigenetic mechanism-regulated changes in gene expression. Previously, we reported that zinc treatment rapidly decreased Lys(4)-trimethylated and Lys(9)-acetylated histone H3 in the metallothionein (MT) promoter, and also decreased total histone H3. The chromatin structure in the MT promoter may be locally disrupted by zinc-induced nucleosome removal. We also showed that chromium (VI) inhibited MT gene transcription by modifying the transcription potential of the co-activator p300. MT is a small cysteine-rich protein that is active in zinc homeostasis, cadmium detoxification, and protection against reactive oxygen species. Epigenetic changes might influence the cytoprotective function of the MT gene. In this review, I briefly summarize the results of previous studies and discuss the mechanisms and toxicological significance of metal-mediated epigenetic modifications.<br>

収録刊行物

• 薬学雑誌

  薬学雑誌 137 (3), 273-279, 2017-03-01

  公益社団法人 日本薬学会

キーワード

• epigenetics
• metallothionein
• cadmium
• chromium
• zinc

詳細情報

• CRID: 1390001206127312000
• NII論文ID: 130005396876
• NII書誌ID: AN00284903
• DOI: 10.1248/yakushi.16-00230-4
• ISSN: 13475231
• ISSN: 00316903
• NDL書誌ID: 028020003
• PubMed: 28250320
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I028020003
• Web Site: https://www.jstage.jst.go.jp/article/yakushi/137/3/137_16-00230-4/_pdf
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可