Bone Histology of Two Cases with Osteomalacia Related to Low-dose Adefovir
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- Hiramatsu Rikako
- Nephrology Center, Toranomon Hospital, Japan
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- Ubara Yoshifumi
- Nephrology Center, Toranomon Hospital, Japan Okinaka Memorial Institute for Medical Research, Toranomon Hospital, Japan
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- Sawa Naoki
- Nephrology Center, Toranomon Hospital, Japan
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- Hasegawa Eiko
- Nephrology Center, Toranomon Hospital, Japan
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- Kawada Masahiro
- Nephrology Center, Toranomon Hospital, Japan
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- Imafuku Aya
- Nephrology Center, Toranomon Hospital, Japan
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- Sumida Keiichi
- Nephrology Center, Toranomon Hospital, Japan
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- Hoshino Junichi
- Nephrology Center, Toranomon Hospital, Japan
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- Takaichi Kenmei
- Nephrology Center, Toranomon Hospital, Japan Okinaka Memorial Institute for Medical Research, Toranomon Hospital, Japan
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抄録
<p>We performed a bone histomorphometric analysis in two patients demonstrating Fanconi syndrome with hypophosphatemia, adefovir-related bone disease and chronic hepatitis B infection. Both patients had osteomalacia, but showed two different histological patterns. The osteoid volume of the patient without risedronate increased with [(osteoid volume/ bone volume)×100=18.6%]. However, the osteoid volume of the patient receiving risedronate without vitamin D analogue showed a greater increase of 53.8%. In both patients bone pain and hypophosphatemia subsided soon after the discontinuation of adefovir and the administration of phosphate derivative. These findings show that bisphosphonate may worsen this disease when this drug is administered without a vitamin D analogue. </p>
収録刊行物
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- Internal Medicine
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Internal Medicine 55 (20), 3013-3019, 2016
一般社団法人 日本内科学会