Peking University - Juntendo University Joint Symposium on Brain and Skin Diseases

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  • NIYONSABA FRANÇOIS
    Faculty of International Liberal Arts, Juntendo University Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine
  • OGAWA HIDEOKI
    Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine

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  • Antimicrobial Peptides: an Essential Component of the Skin Defensive Barrier

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<p>Our skin forms an effective barrier against pathogens and water loss. This is partly mediated by antimicrobial/host defence peptides (AMPs/HDPs). Among these peptides, human β-defensins and LL-37 are the most widely characterized today. They are not only endogenous antibiotics but also display various immunomodulatory functions, including promoting chemotaxis, stimulating the production of cytokines/chemokines, regulating apoptosis, and inducing angiogenesis. Our aim was to review various activities of AMPs/HDPs in keratinocytes, such as regulation of skin barrier function, acceleration of wound healing, promotion of cell differentiation, and inhibition of itching. Therefore, AMPs/HDPs may serve as novel anti-infective and immunomodulatory agents.</p>

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