女性から男性への性転換症者の性腺刺激ホルモン分泌パターンから見た非典型的性アイデンティティの脳基盤

• 貴邑 冨久子

  横浜市大・院・医・神経内分泌学

• 舩橋 利也

  横浜市大・院・医・神経内分泌学

• 木原 彬

  横浜市大・院・医・神経内分泌学

• 榊原 秀也

  横浜市大・院・医・生殖生育病態医学

• 平原 史樹

  横浜市大・院・医・生殖生育病態医学

書誌事項

タイトル別名

• Brain mechanism of atypical sexual identity, based on the gonadotropin secretory pattern in female-to-male transsexuals

抄録

The central part of the bed nucleus of the stria terminalis was shown to be sexually dimorphic, i.e., smaller in women, with a female volume and neuron number in male-to-female transsexuals. The interstitial nuclei of the anterior hypothalamus (INAH) 3 was also sexually dimorphic, i.e., more than twice as large in heterosexual men than in homosexual men. These findings indicate that each sexual identity and sexual orientation has a different biological substrate. We studied the gonadotropin secretory pattern in 4 21-27 year-old female-to-male transsexual women (FTMs). In 2 FTMs, the surge secretion of LH was atypical, showing extremely low amplitudes, in accord with the clinical diagnosis of anovulatory menstrual cycles based on the basal body temperature (BBT), whereas pulsatile secretions of LH in both follicular and luteal phases were typical. One of these FTMs was bisexual and another homosexual. Two other FTMs showed almost typical LH secretory patterns and BBT during the cycle, being homosexual. Although it is controversial whether the control mechanism for gonadotropin secretion in the human hypothalamus is sexually dimorphic, we assume that FTMs are atypical not only in sexual identity, but also in sexual orientation and the control of gonadotropin secretion, suggesting that they have a general hypothalamic sexual differentiation disorder (GHSDD). [Jpn J Physiol 54 Suppl:S41 (2004)]

収録刊行物

• 日本生理学会大会発表要旨集

  日本生理学会大会発表要旨集 2004 (0), S41-S41, 2004

  一般社団法人　日本生理学会

キーワード

• Transsexuals
• Luteinizing hormone
• Sexual identity
• Sexual orientation
• Sexual differentiation

詳細情報

• CRID: 1390001205727103360
• NII論文ID: 130005447311
• DOI: 10.14849/psjproc.2004.0_s41_3
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可