歩行運動の発現における脊髄抑制性ニューロンの役割

• 西丸 広史

  産総研・脳神経情報

書誌事項

タイトル別名

• Roles of inhibitory interneurons in the spinal locomotor circuit of developing rodents

抄録

Limb movements during walking in mammals are highly coordinated. The basic spatial and temporal activity patterns of each muscle during such movements are generated in a neuronal circuit in the spinal cord. In this circuit also called the central pattern generator (CPG), synaptic inhibition mediated by inhibitory neurons is considered to be an important element. In vitro isolated spinal cord preparations from neonatal rats and mice have been widely used to study the neuronal mechanism underlying locomotion in mammals. Utilizing this preparation, we have previously shown that GABA and glycine, two major neurotransmitters in the spinal cord, each play important roles in the coordination of the left and right limb activity and its maturation in the prenatal period. Recent studies utilizing genetically engineered mice have facilitated the investigation of the activity and roles of identified interneurons during locomotion. We have recently recorded the activity of Renshaw cells, a population of inhibitory neurons that form recurrent inhibitory connections to motor neurons in isolated spinal cord preparations taken from GAD67EGFP-knock-in mouse neonates. Their synaptic inputs and firing patterns during locomotor-like motor activity suggested that Renshaw cells play a role in regulating the firing of motor neurons during locomotion in rodents. Furthermore, these recordings revealed that Renshaw cells are modulated by the CPG while their firing is not essential for the generation of locomotor activity. [J Physiol Sci. 2007;57 Suppl:S23]

収録刊行物

• 日本生理学会大会発表要旨集

  日本生理学会大会発表要旨集 2007 (0), 023-023, 2007

  一般社団法人　日本生理学会

キーワード

• locomotion
• spinal cord
• inhibition
• motor
• interneuron

詳細情報

• CRID: 1390001205728173312
• NII論文ID: 130005448714
• DOI: 10.14849/psjproc.2007.0_023_2
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可