サル一次視覚野における5-HT1Bおよび5-HT2A受容体の活動依存的な修飾効果

• 定金 理

  基礎生物学研究所・脳生物

• 渡我部 昭哉

  基礎生物学研究所・脳生物

• 小松 勇介

  基礎生物学研究所・脳生物

• 七五三木 聡

  大阪大院・医

• 内藤 智之

  大阪大院・医

• 尾崎 弘展

  大阪大院・医

• 佐藤 宏道

  大阪大院・医

• 山森 哲雄

  基礎生物学研究所・脳生物

書誌事項

タイトル別名

• Activity-dependent effects of 5-HT1B and 5-HT2A receptors in macaque V1

抄録

We report that the mRNAs of two serotonin receptor subtypes, 5-HT1B and 5HT2A, are specifically expressed in the primary visual cortex (V1) of macaque monkeys and that the strength of expression is controlled in an activity-dependent manner. To elucidate functional roles of these receptors in vivo, we performed electrophysiological recordings of visual responses from 101 V1 neurons with microiontophoretic administration of specific drugs for each receptor subtypes in anesthetized and paralyzed monkeys. The effects of activating these receptors seemed to be bidirectional depending on the activity levels of each neuron. The effect of agonist for 5-HT1B receptor, CP93129, was more facilitatory when the firing rate was high, but the effect was more suppressive when the firing rate was low. The effect of DOI, agonist for 5-HT2A receptor, was opposite in direction. That is, the effect of DOI was more suppressive when the firing rate was high, but more faciliatatory when the firing rate was low. Highly restricted expressions of these receptors and their neural-activity-dependent actions in V1 suggest that 5-HT1B and 5-HT2A receptors complementarily control the gain of input-output relation of V1 with an activity-dependent manner, which could modulate further processing in the cortical network. [J Physiol Sci. 2007;57 Suppl:S100]

収録刊行物

• 日本生理学会大会発表要旨集

  日本生理学会大会発表要旨集 2007 (0), 100-100, 2007

  一般社団法人　日本生理学会

キーワード

• serotonin
• visual cortex
• monkey

詳細情報

• CRID: 1390282680705766784
• NII論文ID: 130005448869
• DOI: 10.14849/psjproc.2007.0_100_4
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可