小脳ネットワーク発達における呼吸性活動の関与の可能性

• 荒田 晶子

  理化学研究所・脳科学総合研究センター・記憶学習機構研究チーム

• 藤井 盛光

  理化学研究所・脳科学総合研究センター・記憶学習機構研究チーム

• 伊藤 正男

  理化学研究所・脳科学総合研究センター・記憶学習機構研究チーム

書誌事項

タイトル別名

• Respiratory activities optically recorded from the newborn rat cerebellum and related medullary structures

抄録

Using optical imaging with voltage-sensitive dye in newborn rat cerebellum-pons-medulla (-spinal cord) block preparations, we recorded respiratory activities in the cerebellum, rostral ventrolateral medulla (RVLM), inferior olive and nucleus parabrachialis (NPB). Cycle triggering with C4 inspiratory activity revealed optical responses distributed in the lateral part of VII-VIII lobules, paraflocculus, lateral end of vermis and also the dorsal respiratory group (DRG) in the dorsal view of the medulla. There are two types of respiratory pathways in the cerebellum related to pulmonary afferent and respiratory rhythm. Vagus nerve stimulation activated the nucleus tractus solitarii (NTS), NPB and also ipsilateral hemisphere of the cerebellum. It is notable that respiratory neuronal activities in the cerebellum are mediated by the inferior olive and NPB. It was confirmed using DiI transport that the inferior olive projects to the paraflocculus and lateral hemisphere around VII-VIII lobule, while it receives input from the neurons below the ambiguus nucleus. The present results indicate that respiratory activities are major sources of both climbing fiber and mossy fiber inputs to the cerebellum in the neonatal stage. These activities may play a role in the activity-dependent formation of cerebellar neuronal circuitry. [J Physiol Sci. 2007;57 Suppl:S215]

収録刊行物

• 日本生理学会大会発表要旨集

  日本生理学会大会発表要旨集 2007 (0), 215-215, 2007

  一般社団法人　日本生理学会

キーワード

• brain block preparation
• respiratory rhythm
• cerebellum
• optical imaging

詳細情報

• CRID: 1390001205728779648
• NII論文ID: 130005449169
• DOI: 10.14849/psjproc.2007.0_215_2
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可