Investigation of Biodistribution and Speciation Changes of Orally Administered Dual Radiolabeled Complex, Bis(5-chloro-7-[¹³¹I]iodo-8-quinolinolato)[⁶⁵Zn]zinc

• Munekane Masayuki

  Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University Japan Society for the Promotion of Science Next-Generation Imaging Team, RIKEN Center for Life Science Technologies

• Ueda Masashi

  Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University

• Motomura Shinji

  Next-Generation Imaging Team, RIKEN Center for Life Science Technologies

• Kamino Shinichiro

  Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University Next-Generation Imaging Team, RIKEN Center for Life Science Technologies

• Haba Hiromitsu

  RIKEN Nishina Center for Accelerator-Based Science, RIKEN

• Yoshikawa Yutaka

  Department of Health, Sports, and Nutrition Faculty of Health and Welfare, Kobe Women’s University

• Yasui Hiroyuki

  Department of Analytical and Bioinorganic Chemistry, Division of Analytical and Physical Chemistry, Kyoto Pharmaceutical University

• Enomoto Shuichi

  Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University Next-Generation Imaging Team, RIKEN Center for Life Science Technologies

書誌事項

タイトル別名

• Investigation of Biodistribution and Speciation Changes of Orally Administered Dual Radiolabeled Complex, Bis(5-chloro-7-[¹³¹I]iodo-8-quinolinolato)[⁶⁵Zn]zinc

抄録

Many zinc (Zn) complexes have been developed as promising oral antidiabetic agents. In vitro assays using adipocytes have demonstrated that the coordination structures of Zn complexes affect the uptake of Zn into cells and have insulinomimetic activities, for which moderate stability of Zn complexes is vital. The complexation of Zn plays a major role improving its bioavailability. However, investigation of the speciation changes of Zn complexes after oral administration is lacking. A dual radiolabeling approach was applied in order to investigate the speciation of bis(5-chloro-7-iodo-8-quinolinolato)zinc complex [Zn(Cq)₂], which exhibits the antidiabetic activity in diabetic mice. In the present study, ⁶⁵Zn- and ¹³¹I-labeled [Zn(Cq)₂] were synthesized, and their biodistribution were analyzed after an oral administration using both invasive conventional assays and noninvasive gamma-ray emission imaging (GREI), a novel nuclear medicine imaging modality that enables analysis of multiple radionuclides simultaneously. The GREI experiments visualized the behavior of ⁶⁵Zn and [¹³¹I]Cq from the stomach to large intestine and through the small intestine; most of the administered Zn was transported together with clioquinol (5-chloro-7-iodo-8-quinolinol) (Cq). Higher accumulation of ⁶⁵Zn for [Zn(Cq)₂] than ZnCl₂ suggests that the Zn associated with Cq was highly absorbed by the intestinal tract. In particular, the molar ratio of administered iodine to Zn decreased during the distribution processes, indicating the dissociation of most [Zn(Cq)₂] complexes. In conclusion, the present study successfully evaluated the speciation changes of orally administered [Zn(Cq)₂] using the dual radiolabeling method.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 40 (4), 510-515, 2017

  公益社団法人 日本薬学会

キーワード

• speciation
• zinc (Zn) complex
• dual label
• biodistribution
• gamma-ray emission imaging (GREI)

詳細情報

• CRID: 1390001204633432448
• NII論文ID: 130005530066
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.b16-00945
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 028082273
• PubMed: 28381805
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I028082273
• Web Site: https://www.jstage.jst.go.jp/article/bpb/40/4/40_b16-00945/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2017347187
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
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