Taurine inhibits 2,5-hexanedione-induced oxidative stress and mitochondria-dependent apoptosis in PC12 cells

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  • LI Shuangyue
    Department of Occupational and Environmental Health, Dalian Medical University, China
  • GUAN Huai
    Department of Obstetrics and Gynecology, No. 210 Hospital of PLA, China
  • QIAN Zhiqiang
    Department of Occupational and Environmental Health, Dalian Medical University, China
  • SUN Yijie
    Department of Occupational and Environmental Health, Dalian Medical University, China
  • GAO Chenxue
    Department of Occupational and Environmental Health, Dalian Medical University, China
  • LI Guixin
    Clinical laboratory, the First Affiliated Hospital of Dalian Medical University, China
  • YANG Yi
    Department of neurosurgery, General Hospital of Beijing Military Command, China
  • PIAO Fengyuan
    Department of Occupational and Environmental Health, Dalian Medical University, China
  • HU Shuhai
    College of Stomatology, Dalian Medical University, China

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<p>2,5-hexanedione (HD) is the ultimate neurotoxic metabolite of hexane, causing the progression of nerve diseases in human. It was reported that HD induced apoptosis and oxidative stress. Taurine has been shown to be a potent antioxidant. In the present study, we investigated the protection of taurine against HD-induced apoptosis in PC12 cells and the underlying mechanism. Our results showed the decreased viability and increased apoptosis in HD-exposed PC12 cells. HD also induced the disturbance of Bax and Bcl-2 expression, the loss of MMP, the release of mitochondrial cytochrome c and caspase-3 activation in PC12 cells. Moreover, HD resulted in an increase in reactive oxygen species (ROS) level and a decline in the activities of superoxidedismutase and catalase in PC12 cells. However, taurine pretreatment ameliorated the increased apoptosis and the alterations in key regulators of mitochondria-dependent pathway in PC12 exposed to HD. The increased ROS level and the decreased activities of the antioxidant enzymes in HD group were attenuated by taurine. These results indicate that pretreatment of taurine may, at least partly, prevent HD-induced apoptosis via inhibiting mitochondria-dependent pathway. It is also suggested that the potential of taurine against HD-induced apoptosis may benefit from its anti-oxidative property.</p>

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