BMI, reproductive factors, and breast cancer molecular subtypes: A case-control study and meta-analysis

• Li Hui

  Department of Epidemiology and Biostatistics, West China School of Public Health, Sichuan University

• Sun Xuezheng

  Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill

• Miller Erline

  Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill

• Wang Qiong

  Department of Epidemiology and Biostatistics, West China School of Public Health, Sichuan University Department of Health Service Management, Public Health School, Sun Yat-Sen University

• Tao Ping

  Department of Breast Surgery, Sichuan Cancer Hospital

• Liu Li

  The Comprehensive Guidance Center of Women's Health, Chengdu Women's and Children's Central Hospital

• Zhao Ying

  Department of Epidemiology and Biostatistics, West China School of Public Health, Sichuan University

• Wang Mengjie

  Department of Epidemiology and Biostatistics, West China School of Public Health, Sichuan University

• Qi Yana

  Department of Epidemiology and Biostatistics, West China School of Public Health, Sichuan University

• Li Jiayuan

  Department of Epidemiology and Biostatistics, West China School of Public Health, Sichuan University

抄録

Background: The effects of body mass index (BMI) and reproductive factors may vary among breast cancer molecular subtypes, evidence of which is lacking in East Asia. Methods: From 2002 to 2010, 1256 breast cancer patients and 1416 healthy women were recruited. Anthropometric and reproductive factors were collected from medical charts. Breast cancer subtype was defined by ER, PR, and HER2 status. Polytomous logistic regression was used to evaluate associations between risk factors and breast cancer subtypes, with subgroup analysis by menopausal status. A metaanalysis of relevant published studies in East Asia was also performed. Results: In our case-control study, late menarche was negatively associated with luminal tumor risk (P_trend = 0.03). Higher BMI was associated with risk of both luminal and triple-negative tumors (P_trend<0.001). Late age at first live birth was associated with a 1.41- to 2.08-fold increased risk of all subtypes, while late menopause increased risk by 2.62–5.56 times. Heterogeneity of these associations was not detected for different menopausal statuses. The meta-analysis revealed a positive dose-response relationship between BMI and risk of both luminal and ER-PR- subtypes (P_trend<0.05). Early menarche and nulliparity increased luminal tumor risk by 1.39 and 1.26 times, respectively. Non-breastfeeding also increased the risk of all subtypes. Conclusions: For East Asian women, overweight, late menopause, and lack of breastfeeding appear to increase risk of both luminal and ER–PR– tumors. Early menarche and nulliparity mainly impacted luminal tumor risk. These associations were not impacted by menopausal status.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｅｐｉｄｅｍｉｏｌｏｇｙ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｅｐｉｄｅｍｉｏｌｏｇｙ 27 (4), 143-151, 2017

  日本疫学会

キーワード

• Breast cancer
• East Asia
• Body mass index
• Reproductive factor
• Molecular subtype

詳細情報

• CRID: 1390282679450561536
• NII論文ID: 130005611914
• DOI: 10.1016/j.je.2016.05.002
• ISSN: 13499092
• ISSN: 09175040
• Web Site: http://api.elsevier.com/content/article/PII:S091750401630154X?httpAccept=text/plain
• Web Site: http://api.elsevier.com/content/article/PII:S091750401630154X?httpAccept=text/xml
• Web Site: https://search.jamas.or.jp/link/ui/2018037905
• 本文言語コード: en
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