脂質を基軸とした免疫調節

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  • 武富 芳隆
    公益財団法人東京都医学総合研究所脂質代謝プロジェクト
  • 村上 誠
    公益財団法人東京都医学総合研究所脂質代謝プロジェクト 東京大学大学院医学系研究科疾患生命工学センター 日本医療研究開発機構（AMED）CREST

書誌事項

タイトル別名
  • Immunological Regulation by Bioactive Lipids
  • Symposium Review 脂質を基軸とした免疫調節
  • Symposium Review シシツ オ キジク ト シタ メンエキ チョウセツ

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抄録

　Mast cells originate from hematopoietic stem cells and undergo terminal maturation in the extravascular tissues, in which they are ultimately resident. Mast maturation, phenotype, and function are dictated by the local microenvironment, which has a significant influence on the ability of mast cells to recognize and respond to stimuli. Activation of mast cells can lead to the release of three distinct classes of mediators, including preformed mediators stored in secretory granules, newly transcribed cytokines and chemokines, and de novo-synthesized bioactive lipid mediators. It is currently recognized that bioactive lipids such as arachidonic acid metabolites (prostaglandins and leukotrienes) released from mast cells modulate innate and adaptive immune responses both directly and indirectly through communication with other microenvironmental immune cells or stroma cells. Moreover, mast cells express a variety of lipid receptors and, if activated by bioactive lipids such as arachidonic acid, ω3 fatty acids, lysophospholipids, and their metabolites, can alter the release and production of other mediators including histamine, cytokines, and chemokines, and thereby alter homeostatic or pathophysiological responses. This review focuses on newly identified functional aspects of bioactive lipids with regard to their immune regulation and functional outcomes in both homeostasis and allergic disease.<br>

収録刊行物

  • 薬学雑誌

    薬学雑誌 137 (5), 503-515, 2017-05-01

    公益社団法人 日本薬学会

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