Lutein Enhances Bone Mass by Stimulating Bone Formation and Suppressing Bone Resorption in Growing Mice

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  • Takeda Hiroshi
    Cooperative Major of Advanced Health Science, Tokyo University of Agriculture and Technology
  • Tominari Tsukasa
    Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology Institute of Global Innovation Research, Tokyo University of Agriculture and Technology
  • Hirata Michiko
    Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology
  • Watanabe Kenta
    Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology
  • Matsumoto Chiho
    Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology
  • Grundler Florian M. W.
    Institute of Global Innovation Research, Tokyo University of Agriculture and Technology Institute of Crop Science and Resource Conservation, University of Bonn
  • Inada Masaki
    Cooperative Major of Advanced Health Science, Tokyo University of Agriculture and Technology Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology Institute of Global Innovation Research, Tokyo University of Agriculture and Technology
  • Miyaura Chisato
    Cooperative Major of Advanced Health Science, Tokyo University of Agriculture and Technology Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology Institute of Global Innovation Research, Tokyo University of Agriculture and Technology

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<p>Lutein is a member of the xanthophyll family of carotenoids, which are known to prevent hypoxia-induced cell damage in the eye by removing free radicals. However, its role in other tissues is controversial, and the effects of lutein on bone tissues are unknown. To identify a possible role of lutein in bone tissues, we examined the effects of lutein on bone formation and bone resorption and on femoral bone mass in mice. Lutein enhanced the formation of mineralized bone nodules in cultures of osteoblasts. On the other hand, lutein clearly suppressed 1α, 25-dihydroxyvitamin D3-induced bone resorption as measured by pit formation in organ culture of mouse calvaria. In co-cultures of bone marrow cells and osteoblasts, lutein suppressed 1α, 25-dihydroxyvitamin D3-induced osteoclast formation. In cultures of bone marrow macrophages, lutein suppressed soluble RANKL, the receptor activator of nuclear factor-kappaB (NF-κB) ligand, induced osteoclast formation. When five-week-old male mice were orally administered lutein for 4 weeks, the femoral bone mass was clearly enhanced in cortical bone, as measured by bone mineral density in dual X-ray absorptiometry and micro computed tomography (µCT) analyses. The present study indicates that lutein enhances bone mass in growing mice by suppressing bone resorption and stimulating bone formation. Lutein may be a natural agent that promotes bone turnover and may be beneficial for bone health in humans.</p>

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