小児心臓手術後におけるデクスメデトミジンと抑肝散併用療法の鎮静効果

• 永渕 弘之

  神奈川県立こども医療センター集中治療科

• 熊坂 治

  神奈川県立こども医療センター薬剤科

• 麻生 俊英

  神奈川県立こども医療センター心臓血管外科

書誌事項

タイトル別名

• Sedative effect of combination therapy using dexmedetomidine and Yokukansan in children after cardiac surgery

抄録

Objectives: The study was conducted to compare the combined effect of dexmedetomidine (DEX) and oral or suppository Yokukansan (YKS) on sedation after cardiac surgery in pediatric patients. Methods: Eighteen postoperative patients were divided into three groups according to YKS combined with continued administration of DEX: non-YKS (NY) group, gastric tube (oral) YKS (GY) group, and intrarectal suppository YKS (RY) group. YKS was administered at a dose of 0.1 g/kg every four hours. The sedation level was evaluated using Richmond Agitation-Sedation Scale and Behavioural Observational Pain Scale, and ketamine was administered for patients with scores ≥2 in either scales. The total dose of ketamine administered per body weight was used to define the sedative effect. Results: The ketamine dose (median) was 1.5, 1.0, and 0 mg/kg/day in NY, GY, and RY groups, respectively. Compared with the NY group, the GY group used less ketamine but the difference was not significant (P=0.49) and the RY group used a significantly lower dose (P=0.03). Conclusions: The combination of DEX and suppository YKS was effective for sedation in children after cardiac surgery, while DEX combined with gastric tube (oral) YKS was not sufficient in efficacy.

収録刊行物

• 日本集中治療医学会雑誌

  日本集中治療医学会雑誌 24 (3), 345-347, 2017

  一般社団法人 日本集中治療医学会

キーワード

• dexmedetomidine
• Yokukansan
• children

詳細情報

• CRID: 1390282679420332416
• NII論文ID: 130005661590
• DOI: 10.3918/jsicm.24_345
• ISSN: 1882966X
• ISSN: 13407988
• Web Site: https://www.jstage.jst.go.jp/article/jsicm/24/3/24_24_345/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2017261476
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可