顆粒球吸着療法が奏効した壊疽性膿皮症合併潰瘍性大腸炎の一例

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  • Ulcerative colitis accompanied by pyoderma gangrenosum successfully treated with granulocyte monocyte apheresis : A case report

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<p>A 30-years-old woman was admitted due to chronic diarrhea and foot ulcer. Her clinical grounds and colonoscopic findings were compatible with ulcerative colitis (UC) . The foot ulcer was aseptic, and histopathological examination of the ulcer base showed nonspecific inflammation with neutrophil infiltration and pseudovasculitis ; pyoderma gangrenosum (PG) was hence diagnosed as an extraintestinal complication of UC. We initiated treatment with 5-aminosalicylate (5-ASA) 4,000 mg/day and granulocyte and monocyte adsorption apheresis (GMA) . The response to the treatment was favorable and rapid-acting. After 10 GMA sessions she achieved remission from UC and PG was completely epithelized. We reduced 5-ASA to 3,000 mg/day and continued observation. This report demonstrates the efficacy of GMA for PG in line with recent studies.</p>

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