Increased serum 25(OH)D3 levels in post-menopausal Japanese women with osteoporosis after 3-year bisphosphonate treatment
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- Nakamura Yukio
- Department of Orthopaedic Surgery, Shinshu University
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- Uchiyama Shigeharu
- Department of Orthopaedic Surgery, Shinshu University
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- Kamimura Mikio
- Center of Osteoporosis and Spinal Disorders, Kamimura Orthopaedic Clinic
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- Ikegami Shota
- Department of Orthopaedic Surgery, Shinshu University
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- Komatsu Masatoshi
- Department of Orthopaedic Surgery, Shinshu University
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- Kato Hiroyuki
- Department of Orthopaedic Surgery, Shinshu University
書誌事項
- タイトル別名
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- Increased Serum 25(OH)D<sub>3</sub> Levels in Post-Menopausal Japanese Women with Osteoporosis after 3-Year Bisphosphonate Treatment
この論文をさがす
抄録
<p>Osteoporosis is characterized by the systemic impairment of bone mass, strength, and microarchitecture, leading to an increased risk of fragility fracture. Bisphosphonates (BPs) are the first-line drugs for osteoporosis. Vitamin D is considered to be essential for osteoporotic treatment. However, long-term effects of BPs on the serum levels of 25-hydroxyvitamin D3 (25(OH)D3) are unknown. Accordingly, in this retrospective study, we collected clinical data of 41 post-menopausal Japanese women with osteoporosis treated with BP for over 3 years, without vitamin D supplementation. We measured lumbar and femoral neck bone mineral density (BMD) and serum levels of bone specific alkaline phosphatase (BAP) as a bone formation marker, and tartrate-resistant acid phosphatase (TRACP)-5b as a bone resorption marker, before and after the 3-year treatment. Serum 25(OH)D3, 1,25(OH)2D3, and whole parathyroid hormone (PTH) were also measured. Notably, no fracture occurred during the treatment. Compared with baseline values, 25(OH)D3 levels were significantly increased from 21.6 to 26.4 ng/mL (P = 0.006), despite no vitamin D supplementation. 1,25(OH)2D3 and whole PTH levels tended to be decreased from 62.6 to 57.8 pg/mL and 27.3 to 25.1 pg/mL, respectively. Both bone formation and resorption markers were significantly suppressed (P < 0.01). Both lumbar BMD (7.3% increase) and femoral neck BMD (4.1% increase) were significantly improved (P < 0.0001) after 3 years of the treatment. Thus, even without vitamin D supplementation, serum 25(OH)D3 levels were significantly increased after 3-year BP therapy. These results suggest that vitamin D supplementation might not be required in the long-term BP therapy for osteoporosis.</p>
収録刊行物
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 242 (3), 241-246, 2017
東北ジャーナル刊行会