Methicillin-Susceptible Teicoplanin-Resistant Staphylococcus haemolyticus Isolate from a Bloodstream Infection with Novel Mutations in the tcaRAB Teicoplanin Resistance Operon
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- Bakthavatchalam Yamuna Devi
- Department of Clinical Microbiology, Christian Medical College
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- Sudarsanam Thambu David
- Department of Medicine (Unit II), Christian Medical College
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- Babu Priyanka
- Department of Clinical Microbiology, Christian Medical College
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- Munuswamy Elakkiya
- Department of Clinical Microbiology, Christian Medical College
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- Muthuirulandi Sethuvel Dhiviya Prabaa
- Department of Clinical Microbiology, Christian Medical College
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- Devanga Ragupathi Naveen Kumar
- Department of Clinical Microbiology, Christian Medical College
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- Veeraraghavan Balaji
- Department of Clinical Microbiology, Christian Medical College
書誌事項
- タイトル別名
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- Methicillin-Susceptible Teicoplanin-Resistant <i>Staphylococcus haemolyticus</i> Isolate from a Bloodstream Infection with Novel Mutations in the <i>tcaRAB</i> Teicoplanin Resistance Operon
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抄録
<p>Staphylococcus haemolyticus is a coagulase-negative staphylococcus that is frequently isolated from blood cultures. Here, we report a case of methicillin-susceptible S. haemolyticus that is resistant to teicoplanin (TEC) and heteroresistant to vancomycin (VAN). The isolate was susceptible to cefoxitin and resistant to TEC by Etest. Population analysis profile-area under the curve analysis confirmed the presence of a VAN heteroresistant subpopulation. Next-generation sequencing analysis of the genome revealed the presence of blaZ and msr(A), which encode cross-resistance to macrolide, lincosamide, and streptogramin B, and the quinolone resistance-conferring gene norA. In addition, several amino acid substitutions were observed in the TEC resistance operon tcaRAB, including I3N, I390N, and L450I in tcaA and L44V, G52V, and S87P in tcaR, as well as in the transpeptidase encoding gene walK (D336Y, R375L, and V404A) and L315 and P316 in graS. We hypothesized that this combination of mutations could confer TEC resistance and reduced VAN susceptibility.</p>
収録刊行物
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- Japanese Journal of Infectious Diseases
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Japanese Journal of Infectious Diseases 70 (4), 458-460, 2017
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
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詳細情報 詳細情報について
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- CRID
- 1390001206239596032
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- NII論文ID
- 130005851921
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- NII書誌ID
- AA1132885X
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- ISSN
- 18842836
- 13446304
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- NDL書誌ID
- 028403382
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- PubMed
- 28250264
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可