Chromium Exposure and Risk of Cardiovascular Disease in High Cardiovascular Risk Subjects　― Nested Case-Control Study in the Prevention With Mediterranean Diet (PREDIMED) Study ―

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  • Gutiérrez-Bedmar Mario
    Department of Preventive Medicine and Public Health, University of Málaga The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD 06/0045), Instituto de Salud Carlos III (ISCIII)
  • Martínez-González Miguel Ángel
    The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD 06/0045), Instituto de Salud Carlos III (ISCIII) Department of Preventive Medicine and Public Health, University of Navarra Medical School CIBER Pathophysiology of Obesity and Nutrition, Carlos III Health Institute Department of Nutrition, Harvard TH Chan School of Public Health
  • Muñoz-Bravo Carlos
    Department of Preventive Medicine and Public Health, University of Málaga
  • Ruiz-Canela Miguel
    The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD 06/0045), Instituto de Salud Carlos III (ISCIII) Department of Preventive Medicine and Public Health, University of Navarra Medical School CIBER Pathophysiology of Obesity and Nutrition, Carlos III Health Institute
  • Mariscal Alberto
    Department of Preventive Medicine and Public Health, University of Málaga
  • Salas-Salvadó Jordi
    The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD 06/0045), Instituto de Salud Carlos III (ISCIII) CIBER Pathophysiology of Obesity and Nutrition, Carlos III Health Institute Human Nutrition Unit, Biochemistry and Biotechnology Department, IISPV, Rovira i Virgili University
  • Estruch Ramón
    CIBER Pathophysiology of Obesity and Nutrition, Carlos III Health Institute Department of Internal Medicine, Hospital Clinic, Institut d’Investigacions Biomèdiques August Pi Sunyer (IDIBAPS)
  • Corella Dolores
    CIBER Pathophysiology of Obesity and Nutrition, Carlos III Health Institute Department of Preventive Medicine and Public Health, School of Medicine, University of Valencia
  • Arós Fernando
    The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD 06/0045), Instituto de Salud Carlos III (ISCIII) CIBER Pathophysiology of Obesity and Nutrition, Carlos III Health Institute Department of Cardiology, University Hospital of Araba
  • Fito Monserrat
    CIBER Pathophysiology of Obesity and Nutrition, Carlos III Health Institute Cardiovascular Risk and Nutrition Unit, Hospital del Mar Institut for Medical Research (IMIM)
  • Lapetra José
    CIBER Pathophysiology of Obesity and Nutrition, Carlos III Health Institute Department of Family Medicine, Research Unit, Sanitary District Primary Care Sevilla
  • Serra-Majem Lluís
    The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD 06/0045), Instituto de Salud Carlos III (ISCIII) CIBER Pathophysiology of Obesity and Nutrition, Carlos III Health Institute Department of Clinical Sciences, University of Las Palmas de Gran Canaria
  • Pintó Xavier
    The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD 06/0045), Instituto de Salud Carlos III (ISCIII) CIBER Pathophysiology of Obesity and Nutrition, Carlos III Health Institute Department of Internal Medicine, Hospital Belvitge
  • Alonso-Gómez Ángel
    The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD 06/0045), Instituto de Salud Carlos III (ISCIII) CIBER Pathophysiology of Obesity and Nutrition, Carlos III Health Institute Department of Cardiology, University Hospital of Araba
  • Portoles Olga
    CIBER Pathophysiology of Obesity and Nutrition, Carlos III Health Institute Department of Preventive Medicine and Public Health, School of Medicine, University of Valencia
  • Fiol Miquel
    CIBER Pathophysiology of Obesity and Nutrition, Carlos III Health Institute Palma Institute of Health Research (IdISPa), Hospital Son Espases
  • Bulló Mónica
    The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD 06/0045), Instituto de Salud Carlos III (ISCIII) CIBER Pathophysiology of Obesity and Nutrition, Carlos III Health Institute Human Nutrition Unit, Biochemistry and Biotechnology Department, IISPV, Rovira i Virgili University
  • Castañer Olga
    CIBER Pathophysiology of Obesity and Nutrition, Carlos III Health Institute Cardiovascular Risk and Nutrition Unit, Hospital del Mar Institut for Medical Research (IMIM)
  • Ros Emilio
    CIBER Pathophysiology of Obesity and Nutrition, Carlos III Health Institute Lipid Clinic, Endocrinology and Nutrition Service, Hospital Clinic, Institut d’Investigacions Biomèdiques August Pi Sunyer (IDIBAPS)
  • Gómez-Gracia Enrique
    Department of Preventive Medicine and Public Health, University of Málaga The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD 06/0045), Instituto de Salud Carlos III (ISCIII)

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<p>Background:Epidemiological data on chromium (Cr) exposure and the risk of cardiovascular disease (CVD) are still limited. Toenail Cr level (TCL) provides a time-integrated measure reflecting long-term Cr exposure. We measured TCL to assess the hypothesis that long-term Cr exposure was inversely associated with incident CVD in a population at high risk for CVD.</p><p>Methods and Results:The associations between TCL and CVD were evaluated in a case-control study nested within the “PREvención con DIeta MEDiterránea” (PREDIMED) trial. We randomly selected 147 of the 288 patients diagnosed with CVD during follow-up and matched them on age and sex to 271 controls. Instrumental neutron activation analysis was used to assess TCL. In-person interviews, medical record reviews, and validated questionnaires were used to assess covariates. The fully adjusted OR for the highest vs. lowest quartile of toenail Cr was 0.54 (95% CI: 0.26–1.14; Ptrend=0.189) for the nested case-control study. On stratification for diabetes mellitus (DM), OR was 1.37 (95% CI: 0.54–3.46; Ptrend=0.364) for the DM group, and 0.25 (95% CI: 0.08–0.80; Ptrend=0.030) for the non-DM group (P for interaction=0.078).</p><p>Conclusions:The present findings, although not statistically significant, are consistent with previously reported inverse associations between TCL and CVD. These results, especially for non-DM patients, increase the limited epidemiological knowledge about the possible protective role of Cr against CVD. (Trial registration: www.controlled-trials.com; ISRCTN35739639.)</p>

収録刊行物

  • Circulation Journal

    Circulation Journal 81 (8), 1183-1190, 2017

    一般社団法人 日本循環器学会

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