マイクロロッド式ディスペンサを用いた生体溶解性マイクロニードルパッチの製作に関する研究

DOI

書誌事項

タイトル別名
  • A Cost-Efficient Fabrication Method of Micro-Needle Based on Rod-Assisted Dispenser

抄録

Micro-needle is a micron size needle which can insert into our skin and realize painless drug delivery. Micro-needle has attracted much attention in the past years due to its wide-spread using for transdermal drug delivery. In addition, its ability of penetrating into the skin in a minimally-invasive and painless method shows the attractive application potential.The conventional fabrication methods of micro-needle, such as micro-mold based or drawing lithography, have some problems such as the limitation of materials and aspect ratio of needle shape, also the waste of materials during the fabrication. In this work, we demonstrate a novel fabrication method using micro dispenser to substitute the conventional fabrication method. By using micro dispenser, simple and continuous fabrication process as well as reduce the material waste during the mass production can be achieved. We achieved the micro-needle whose height is from 300 μm to 600 μm while the tip diameter is around 50 μm. It is expected that uniform dimensions of micro-needles can be achieved by adjusting experimental parameters. We expect that our fabrication method using micro dispenser can be used to fabricate various shapes and materials of micro-needle.

収録刊行物

キーワード

詳細情報 詳細情報について

  • CRID
    1390001205658889088
  • NII論文ID
    130006043778
  • DOI
    10.11522/pscjspe.2017s.0_329
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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