3-compartment pharmacokinetic model for estimation of talaporfin sodium concentration in interstitial space

• UNO Yuko

  School of Fundamental Science and Technology, Graduate School of Science and Technology, Keio University

• OGAWA Emiyu

  School of Fundamental Science and Technology, Graduate School of Science and Technology, Keio University

• ARAI Tsunenori

  School of Fundamental Science and Technology, Graduate School of Science and Technology, Keio University Department of Applied Physics and Physico-Informatics, Faculty of Science and Technology, Keio University

Abstract

We constructed a 3-compartment pharmacokinetic model for canine consisted of three compartments including plasma, interstitial space, and cell to estimate talaporfin sodium concentration change in interstitial space. Photosensitization reaction is performed when talaporfin sodium distributes in the interstitial space employing a short drug-light interval in our arrhythmia ablation. We studied interstitial concentration constructing the 3-compartment numerical model using talaporfin sodium concentration in canine plasma, and in addition, other measured relative concentrations of canine tissue, including plasma, interstitial space and cell information. We represented differential rate equation of the drug concentration in each compartment. Fitting the measured data set to the calculated concentration in each compartment, the rate constants in the constructed 3-compartment model were determined with R2=0.98. Using the 3-compartment model, the interstitial talaporfin sodium concentration and the available condition in our arrhythmia ablation could be estimated.

Journal

• Transactions of Japanese Society for Medical and Biological Engineering

  Transactions of Japanese Society for Medical and Biological Engineering 55Annual (Proc), 550-551, 2017

  Japanese Society for Medical and Biological Engineering

Keywords

• talaporfin sodium
• pharmacokinetics
• 3-compartment model
• interstitial space

Details

• CRID: 1390001205270407296
• NII Article ID: 130006077251
• DOI: 10.11239/jsmbe.55annual.550
• ISSN: 18814379
• ISSN: 1347443X
• Text Lang: en
• Data Source:
  • JaLC
  • CiNii Articles
  • Crossref
• Abstract License Flag: Disallowed